20.500.12556/DiRROS-22929 Contact urticaria and related conditions: clinical review Contact urticaria and related conditions Contact urticaria (CoU) is an immediate contact reaction occurring within minutes to an hour after exposure to specific proteins or chemicals. CoU is categorised into non-immunologic (NI-CoU) and immunologic (I-CoU) types, with I-CoU potentially leading to anaphylaxis. Both forms of CoU can be associated with protein contact dermatitis and the CoU syndrome. Patients with I-CoU may also have other type I (immediate) allergic diseases, such as allergic conjunctivitis, rhinitis, asthma or food allergy. This review provides a detailed overview of CoU and related conditions, focusing on triggers, diagnostic methods and management strategies. NI-CoU is typically triggered by low molecular weight chemicals, while I-CoU involves IgE-mediated hypersensitivity to both high molecular weight proteins and low molecular weight chemicals. Early diagnosis is crucial, though CoU is often underrecognized. The diagnostic approach includes a thorough medical history, physical examination, evaluation of photographs, (non)invasive skin tests and in vitro assessments. Management strategies prioritise trigger avoidance and pharmacological treatments when avoidance is not fully possible. For I-CoU, second-generation H1-antihistamines are the first-line treatment. Severe cases of I-CoU may benefit from anti-IgE therapy (omalizumab). Patients at risk of anaphylaxis should carry an adrenaline auto-injector and wear a medical alert bracelet. inducible urticaria occupational urticaria protein contact dermatitis izzvana urtikarija poklicna urtikarija dermatitis ob stiku z beljakovinami true false true Angleški jezik Slovenski jezik © 2025 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd. Neznano 2025-07-09 07:59:11 2025-07-09 07:59:11 2025-10-24 03:52:46 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Avtorji iz Slovenije: Mojca Bizjak, Mitja Košnik, Mark Kačar; Opis vira z dne 10. 4. 2025; str. 87-107 issue 2 Vol. 93 Aug 2025 0000-00-00 Zaloznikova Objavljeno apc 2024-11-01 2025-03-06 2025-08-01 616.5-002:616.97 1600-0536 10.1111/cod.14794 232153859 https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14794 1 d69ea1b7-5c89-11f0-8080-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=33409 RAZ_Aerts_Olivier_2025.pdf RAZ_Aerts_Olivier_2025.pdf 1 ED11AAFE98A1BA15DE6D23BDA554A107 6a2ffba9458854a77962d62ed1b8e1426e13f55e9aa5b287a8924917fa99b615 a01c911b-5c8a-11f0-8080-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=33410 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0