20.500.12556/DiRROS-22795 Epidemiological and clinical insights into enterovirus circulation in Europe, 2018 - 2023 a multi-center retrospective surveillance study Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age, and clinical presentations in Europe from 2018 to 2023. Methods Aggregated data were requested from the European Centre for Disease Prevention and Control National Focal Points for Surveillance and European Non-Polio Enterovirus Network. Data included detection month, specimen type, age group, and clinical presentation for the 10 most commonly reported EV types per year. Results Twenty-eight institutions (16 countries) reported 563 654 EV tests during the study period with 33 265 (5.9%) EV positive. Forty-two types were identified (n = 11 605 cases) with echovirus 30 (E30), coxsackievirus A6 (CVA6), EV-D68, E9, E11, CVB5, E18, CVB4, EV-A71, and E6 most frequently reported. E30 declined after 2018/2019, while CVA6, CVB5, E9, E11, and EV-D68 were prevalent both before and after the coronavirus disease 2019 (COVID-19) pandemic, and CVB4 and E18 were prevalent after the pandemic. A shift in seasons (summer to fall) and specimen positivity (feces to respiratory) was observed. Neurological signs predominated among EV-A71, CVB4, CVB5, E6, E9, E11, E18, and E30 (30%–72%). CVB4, CVB5, E9, E11, and E18 were frequently reported among neonates (18%–32%). CVA6 was frequently associated with hand, foot and mouth disease, and EV-D68 with respiratory infections. Paralysis was reported among 22 infections, associated with 10 nonpolio types. Conclusions This study emphasizes the widespread circulation and severity of EV infections in Europe, as well as the (re)emergence of specific types postpandemic. Our findings highlight the need for continuous EV surveillance to monitor variation in circulation, age, and clinical presentations, including paralysis among nonpolio EV infections. enterovirus laboratory detection surveillance Europe epidemiology true false true University of Chicago Press for the Infectious Diseases Society of America Angleški jezik Ni določen Neznano 2025-06-27 07:20:49 2025-06-27 07:47:36 2025-10-24 03:52:11 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 6. 2025; Soavtorji: Emiel Vanhulle, Anne Ingenbleek, Leonidas Alexakis, Caroline Klint Johannesen, Eeva K Broberg, Heli Harvala, Thea K Fischer, Kimberley S. M. Benschop on behalf of ENPEN study collaborators; Str. 1-12 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-02-05 2025-04-03 2025-04-04 579 1537-6613 10.1093/infdis/jiaf179 237954051 https://doi.org/10.1093/infdis/jiaf179 0 de2c33bd-5319-11f0-8080-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=33124 de_Schrijver_et_al_2025_Epidemiological_and_clinical_insights.pdf de_Schrijver_et_al_2025_Epidemiological_and_clinical_insights.pdf 1 4E6A214FE3D05320D41272FE47687417 f0614fc267717403bebc6abec70d1733e9d2dcbb50723ffb7c68d8dcda96eab0 b53b6b2d-5319-11f0-8080-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=33121 Nacionalni laboratorij za zdravje, okolje in hrano 0 0 0