20.500.12556/DiRROS-22542 Bronchial bacterial colonization and the susceptibility of isolated bacteria in patients with lung malignancy Bronhialna bakterijska kolonozacija in občutljivost izoliranih bakterij pri bolnikih z rakom na pljučih Background Postoperative pneumonia (POP) remains a leading cause of mortality following lung surgery. Recent studies have confirmed that the respiratory tract below the vocal cords is not sterile and often harbours potentially pathogenic microorganisms (PPMs), putting patients with lung malignancies at an increased risk for pulmonary infections. Patients and methods The study analysed 149 patients who underwent bronchoscopy for lung lesions suspected to be lung cancer. Protected specimen brush (PSB) samples were obtained during bronchoscopy prior to any specific treatment. Bacterial identification and antimicrobial susceptibility testing were conducted on the isolated strains. Results Bacterial colonization was detected in 88.6% of patients, with 21.5% carrying PPMs. Notably, patients with type 2 diabetes exhibited a higher rate of PPM colonization compared to others. Antibiotic susceptibility testing showed no significant differences in efficacy between amoxicillin with clavulanic acid and first-generation cephalosporin in both colonized patients and those with PPMs. Importantly, no multidrug-resistant bacteria were identified. Conclusions Our findings indicate a slightly lower PPM colonization rate compared to previous studies, possibly due to the unique geographic characteristics of the study population. The absence of significant differences in bacterial susceptibility between the two tested antibiotics highlights the need for further research to refine perioperative infection management strategies. bronchial bacterial colonization potentially pathogenic microorganisms antibiotic prophylaxis bakterijska kolonizacija bronhijev potencialno patogeni mikroorganizmi antibiotična profilaksa true false true Association of Radiology and Oncology Radiology and oncology Angleški jezik Slovenski jezik © 2025 Sabrina Petrovic et al., published by Sciendo This work is licensed under the Creative Commons Attribution 4.0 International License. Neznano 2025-06-03 09:59:06 2025-06-03 09:59:07 2026-06-17 13:22:30 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne: 7. 3. 2025; str. 147-152 iss. 1 Vol. 59 Mar. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2024-04-15 2025-01-19 2025-03-01 616-022.1:615.33 1318-2099 10.2478/raon-2025-0018 228325123 RAZ_Beovic_Bojana_2025.pdf RAZ_Beovic_Bojana_2025.pdf 1 E0714C4B49ADC97876BFCDB4B3C7CF42 169d201aefbe9f26718c64e77276f7049fe338ef06e152aa06179195bfe8635e ce555849-4051-11f0-963a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=32593 https://sciendo.com/article/10.2478/raon-2025-0018 1 cb3e37a8-6a3e-11f1-97b2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=45749 https://sciendo.com/article/10.2478/raon-2025-0018 0 92eafcd3-4052-11f0-963a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=32595 Društvo radiologije in onkologije 0 0 0