20.500.12556/DiRROS-22064 Neuromotor changes in postural control following bed rest Chronic bed rest (BR) serves as a model for studying the effects of prolongedimmobility on physiological and neuromotor functions, particularly postural control. ProlongedBR leads to significant deconditioning of postural balance control, characterized by increasedsway path lengths, sway velocity and fall risk, independent of muscle strength. These changes arelinked to neural adaptations at spinal and supraspinal levels, including structural and functionalbrain changes, such as alterations in grey and white matter, increased cerebellar activation,reduced spinal excitability and increased latencies within reflex circuitries. Additionally, BRdisrupts sensory integration from proprioceptive, visual and vestibular systems, impairing post-ural stability. Visual reliance remains stable during BR, though decreased visual acuity andcontrast sensitivity are noted. Moreover, BR-induced shifts in cerebrospinal fluid contribute toaltered brain activity, impacting sensorimotor function. Vestibular system adaptations, includingchanges in vestibulospinal reflexes, further exacerbate balance impairments. Understanding thesemechanisms is crucial for developing interventions to mitigate the adverse effects of BR onpostural control and prevent prolonged recovery times or increased risk of injury. This reviewhighlights the need for further research into the neural underpinnings of BR-induced posturalinstability, with a focus on sensory integration and neuroplasticity atrophy balance disuse immobilization muscle atrofija ravnotežje neraba imobilizacija mišica true false false Angleški jezik Slovenski jezik Neznano 2025-04-18 09:31:39 2025-04-18 09:31:39 2025-10-24 03:50:28 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 18. 4. 2025; str. 1-22 iss. Vol. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-01-01 616.8 1469-7793 10.1113/JP285668 233235715 25_04_18_102_Marusic_233235715.pdf 25_04_18_102_Marusic_233235715.pdf 1 9B068DFACE92564E2DCB3FD0EF49C832 00353d4b465cd7fa8388c77fea4c5e296338363f1c3eff87ae00487bcccf05d0 a6e8fd58-1c27-11f0-963a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=31872 https://physoc.onlinelibrary.wiley.com/journal/14697793 1 2bc2f73e-1c27-11f0-963a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=31871 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0