20.500.12556/DiRROS-21161 FoxP3+ regulatory T-cell quantities in nodal T-follicular helper cell lymphomas and peripheral T-cell lymphomas not otherwise specified and their impact on overall survival The role of FoxP3+ regulatory T cells (Tregs) in the tumour microenvironment (TME) of peripheral T-cell lymphomas (PTCLs) is complex, and their impact on overall survival (OS) is unclear. This retrospective study aims to examine the quantity of FoxP3+ cells in the TME of PTCLs and reactive lymph nodes (LNs) and their impact on OS. A lower FoxP3+ cell quantity is found in PTCLs compared to reactive LNs. While differences in OS are observed between groups with high and low FoxP3+ cell quantities using various cut-off values, further analyses show no significant impact on the risk of death. This study suggests FoxP3+ cells as potential prognostic biomarkers but recommends the conduction of larger, multicentre studies with standardized protocols for confirmation. It also indicates that Treg-suppressing drugs may not be suitable for certain PTCL patients. Instead, combining therapies, including those enhancing Treg function, could be more effective in improving outcomes for PTCL patients, warranting further research. lymphoma prognostic biomarkers overall survival limfom napovedni biološki označevalci celokupno preživetje true false true MDPI Basel, Switzerland Angleški jezik Slovenski jezik by Authors Neznano 2025-01-09 07:49:56 2025-01-09 07:49:56 2025-01-10 03:42:38 0000-00-00 00:00:00 2024 0 Basel 0 Nasl. z nasl. zaslona; Opis vira z dne 14. 11. 2024; str. 4011-1-4011-15 iss. 23 Vol. 16 2024 0000-00-00 Zaloznikova Objavljeno apc 2024-09-28 2024-11-25 2024-11-29 616-07 2072-6694 10.3390/cancers16234011 217313539 https://www.mdpi.com/2072-6694/16/23/4011 1 f20b2a67-ce55-11ef-ba3f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=30023 RAZ_Erzar_Eva_2024.pdf RAZ_Erzar_Eva_2024.pdf 1 77985348199F13D9E79E38172AD1EC4D db7f40a9db1a2b78a68a74eb5f2374902279e728ead13c91552ba2d717c70414 50ce79c4-ce56-11ef-ba3f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=30024 Onkološki inštitut Ljubljana 0 0 0