20.500.12556/DiRROS-21160 The impact of bone marrow involvement on prognosis in diffuse large B-cell lymphoma an 18F-FDG PET/CT volumetric segmentation study Background: This study assessed the prognostic value of tumor burden in bone marrow (BM) and total disease (TD), as depicted on 18F-FDG PET/CT in 140 DLBCL patients, for complete remission after first-line systemic treatment (iCR) and 3- and 5-year overall survival (OS3 and OS5). Methods: Baseline 18F-FDG PET/CT scans of 140 DLBCL patients were segmented to quantify metabolic tumor volume (MTV), total lesion glycolysis (TLG), and SUVmax in BMI, findings elsewhere (XL), and TD. Results: Bone marrow involvement (BMI) presented in 35 (25%) patients. Median follow-up time was 47 months; 79 patients (56%) achieved iCR. iCR was significantly associated with TD MTV, XL MTV, BM PET positivity, and International Prognostic Index (IPI). OS3 was significantly worse with TD MTV, XL MTV, IPI, and age. OS5 was significantly associated with IPI, but not with MTVs and TLGs. Univariate factors predicting OS3 were XL MTV (hazard ratio [HR] = 1.29), BMI SUVmax (HR = 0.56), and IPI (HR = 1.92). By multivariate analysis, higher IPI (HR = 2.26) and BMI SUVmax (HR = 0.91) were significant independent predictors for OS3. BMI SUVmax resulted in a negative coefficient and hence indicated a protective effect. Conclusions: Baseline 18F-FDG PET/CT MTV is significantly associated with survival. BMI identified on 18F-FDG PET/CT allows appropriate treatment that may improve survival. bone marrow diffuse large B-cell lymphoma survival kostni mozeg difuzni velikocelični limfom B preživetje true false false MDPI Basel, Switzerland Angleški jezik Slovenski jezik by Authors Neznano 2025-01-09 07:34:45 2025-01-09 07:34:45 2025-01-10 03:42:38 0000-00-00 00:00:00 2024 0 Basel 0 Nasl. z nasl. zaslona; Opis vira z dne 11. 11. 2024; str. 3762-1-3762-17 no. 22 ǂVol.ǂ16 2024 0000-00-00 Zaloznikova NiDoloceno apc 0000-00-00 0000-00-00 2024-01-01 616.4 2072-6694 10.3390/cancers16223762 214486531 https://www.mdpi.com/2072-6694/16/22/3762 1 d4763349-ce53-11ef-ba3f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=30021 RAZ_Doma_Andrej_2024.pdf RAZ_Doma_Andrej_2024.pdf 1 578771FD22F0D27D733925D390879A9A f2f04eb9681ef50e25d5e61e3974cc6e5d15bc07b34097ede5d6d02f0645c5c5 5156607b-ce54-11ef-ba3f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=30022 Onkološki inštitut Ljubljana 0 0 0