20.500.12556/DiRROS-20525 Selection on the vascular-remodeling BMPER gene is associated with altitudinal adaptation in an insular lizard High altitude imposes several extreme constraints on life, such as low oxygen pressure and high levels of ultraviolet radiation, which require specialized adaptations. Many studies have focused on how endothermic vertebrates respond to these challenging environments, but there is still uncertainty on how ectotherms adapt to these conditions. Here, we used whole-genome sequencing of low-altitude (100–600 m) and high-altitude (3,550 m) populations of the wide-ranging Tenerife lizard Gallotia galloti to uncover signatures of selection for altitudinal adaptation. The studied populations show reduced differentiation, sharing similar patterns of genetic variation. Selective sweep mapping suggests that signatures of adaptation to high altitude are not widespread across the genome, clustering in a relatively small number of genomic regions. One of these regions contains BMPER, a gene involved with vascular remodeling, and that has been associated with hypoxia-induced angiogenic response. By genotyping samples across 2 altitudinal transects, we show that allele frequency changes at this locus are not gradual, but rather show a well-defined shift above ca. 1,900 m. Transcript and protein structure analyses on this gene suggest that putative selection likely acts on noncoding variation. These results underline how low oxygen pressure generates the most consistent selective constraint in high-altitude environments, to which vertebrates with vastly contrasting physiological profiles need to adapt in the context of ongoing climate change. high altitude adaptations ectotherms whole-genome sequencing selective sweep BMPER gene hypoxia genomics visoka nadmorska višina prilagoditve ektotermi sekvenciranje celotnega genoma selektivni zamah BMPER gen hipoksija genomika Gallotia galloti true false true Angleški jezik Slovenski jezik Neznano 2024-10-08 12:16:29 2024-10-08 12:16:29 2025-04-11 03:38:43 0000-00-00 00:00:00 2024 0 0 Soavtorji: Catarina Pinho, Rodrigo Megía-Palma, Prem Aguilar, Anamarija Žagar, Pedro Andrade, Miguel A. Carretero; Nasl. z nasl. zaslona; Članek v PDF formatu obsega 10 str.; Online first: 22 Sept. 2024; Opis vira z dne 8. 10. 2024; 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2024-09-22 575.111 2056-3744 10.1093/evlett/qrae047 210656003 https://doi.org/10.1093/evlett/qrae047 1 65a22e73-855e-11ef-a5bf-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28941 RAZ_Guerra_Seren_Nina_2024.pdf RAZ_Guerra_Seren_Nina_2024.pdf 1 5BC8726816EDCDCE4A7AF7C4413EF33D 88fb751c335c6cb6126863684d212615450579152ef8af83d0e742006f93e0e0 d1f3865b-1081-11f0-963a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=31457 qrae047_suppl_supplementary_tables_s1-s4_figures_s1-s5.pdf qrae047_suppl_supplementary_tables_s1-s4_figures_s1-s5.pdf Dopolnilne informacije 1 D29FE7958DC366A727E7AF6BEDC81ACD a061c95ef7b5447da1ef7f67aaa4e1067b9d8bb287590e29d2632ffad0cb542c 6128ff37-1602-11f0-963a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=31612 Nacionalni inštitut za biologijo 0 0 0