20.500.12556/DiRROS-20163 CXCR4 antagonists as stem cell mobilizers and therapy sensitizers for acute myeloid leukemia and glioblastoma? Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs are localized in protective hypoxic peri-arteriolar niches where these aforementioned stemness properties are maintained. We previously showed that hypoxic peri-arteriolar GSC niches in human glioblastoma are functionally similar to hypoxic peri-arteriolar hematopoietic stem cell (HSC) niches in human bone marrow. GSCs and HSCs express the receptor C-X-C receptor type 4 (CXCR4), which binds to the chemoattractant stromal-derived factor-1α (SDF-1α), which is highly expressed in GSC niches in glioblastoma and HSC niches in bone marrow. This receptor–ligand interaction retains the GSCs/HSCs in their niches and thereby maintains their slowly-dividing state. In acute myeloid leukemia (AML), leukemic cells use the SDF-1α–CXCR4 interaction to migrate to HSC niches and become slowly-dividing and therapy-resistant leukemic stem cells (LSCs). In this communication, we aim to elucidate how disruption of the SDF-1α–CXCR4 interaction using the FDA-approved CXCR4 inhibitor plerixafor (AMD3100) may be used to force slowly-dividing cancer stem cells out of their niches in glioblastoma and AML. Ultimately, this strategy aims to induce GSC and LSC differentiation and their sensitization to therapy. glioblastoma glioblastoma stem cells niches acute myeloid leukemia hematopoietic stem cells bone marrow C-X-C receptor type 4 stromal-derived factor-1 ▫$[alpha]$▫ plerixafor glioblastoma matične celice glioblastoma akutna mielonična levkemija kostni mozeg true false true Angleški jezik Slovenski jezik Neznano 2024-08-06 15:35:55 2024-08-06 15:35:55 2024-08-07 04:07:30 0000-00-00 00:00:00 2020 0 0 Nasl. z nasl. zaslona; Opis vira z dne 30. 3. 2020; str. 1-10 iss. 31 Vol. 9 17 Feb. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2020-02-12 577 2079-7737 10.3390/biology9020031 40521221 https://www.mdpi.com/2079-7737/9/2/31 1 13fa3d9b-53e8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28174 RAZ_Hira_Vashendriya_V._V._2020.pdf RAZ_Hira_Vashendriya_V._V._2020.pdf 1 141860D0097387337E12B9B19A571323 29a64ebf71a28c704c40dffec2d854b05f91ca37dfae3608282c87bb894ef37c 57722fb0-53e8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28175 https://doi.org/10.3390/biology9020031 0 5f9b8186-53e8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28176 Nacionalni inštitut za biologijo 0 0 0