20.500.12556/DiRROS-20142 Nanoparticles for hyperthermic therapy synthesis strategies and applications in glioblastoma Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood–brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM. hyperthermia targeted drug delivery SPIONs gold nanorods carbon nanotubes true false true Angleški jezik Ni določen Neznano 2024-08-06 10:31:46 2024-08-06 10:31:47 2024-08-07 04:07:23 0000-00-00 00:00:00 2014 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 3. 2018; str. 2863-2877 iss. 1 Vol. 9 2014 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2014-06-10 577 1178-2013 10.2147/IJN.S57501 4649295 http://dx.doi.org/10.2147/IJN.S57501 1 94755547-53bd-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28127 RAZ_Verma_Jyoti_2014.pdf RAZ_Verma_Jyoti_2014.pdf 1 3178E1CF1F610BE1223F46D072007A4D 58520dbafc65519de9cb39e6ef1d98260e54cccb558b76b13d874d346d3bb34e c6998cdb-53bd-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28128 Nacionalni inštitut za biologijo 0 0 0