20.500.12556/DiRROS-20137 Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumours Proteolytic enzymes are highly relevant in different processes of cancer progression. Their interplay with other signalling molecules such as cytokines represents important regulation of multicellular cross-talk. In this review, we discuss protease regulation mechanisms of cytokine signalling in various types of cancer. Additionally, we highlight the reverse whereby cytokines have an impact on protease expression in an autocrine and paracrine manner, representing complex feedback mechanisms among multiple members of these two protein families. The relevance of the protease-cytokine axis is illustrated in glioblastoma, where interactions between normal mesenchymal stem cells and cancer cells play an important role in this very malignant form of brain cancer. cellular cross-talk glioblastoma invasion mesenchymal stem cells protease-cytokine signalling true false true Angleški jezik Ni določen Neznano 2024-08-06 10:02:02 2024-08-06 10:02:03 2024-08-08 03:57:20 0000-00-00 00:00:00 2017 0 0 str. 709-719 no. 7 Vol. 398 2017 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2017-01-01 577.2 1431-6730 10.1515/hsz-2016-0283 4176463 RAZ_Breznik_Barbara_2017.pdf RAZ_Breznik_Barbara_2017.pdf 1 BEFC6972CB64EAEFCDB0FE2E4455C366 b746eccff648d8b5d756e8d777d41a1b05dd0c78e817516abe4eb5cd1a536caf cdb55475-53b9-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28113 https://doi.org/10.1515/hsz-2016-0283 0 d8e876b4-53b9-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28114 Nacionalni inštitut za biologijo 0 0 0