20.500.12556/DiRROS-20136 The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblastoma tumor samples. However, other studies have described peri-vascular niches, peri-hypoxic niches, peri-immune niches and extracellular matrix niches of GSCs. The aim of this review was to critically evaluate the literature on these five different types of GSC niches. In the present review, we describe that the five niche types are not distinct from one another, but should be considered to be parts of one integral GSC niche model, the hypoxic peri-arteriolar GSC niche. Moreover, hypoxic peri-arteriolar GSC niches are structural and functional look-alikes of hematopoietic stem cell (HSC) niches in the bone marrow. GSCs are maintained in peri-arteriolar niches by the same receptor-ligand interactions as HSCs in bone marrow. Our concept should be rigidly tested in the near future and applied to develop therapies to expel and keep GSCs out of their protective niches to render them more vulnerable to standard therapies. glioblastoma glioma stem cells niches blood vessels extracellular matrix tumor microenvironment hypoxia therapy resistance vasculature glioblastoma endotelne celice tumorsko mikrookrožje hipoksija true false true Angleški jezik Slovenski jezik Neznano 2024-08-06 09:42:40 2024-08-06 09:42:40 2024-08-08 03:47:45 0000-00-00 00:00:00 2018 0 0 str. 346-354 iss. 2 Vol. 1869 Apr. 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2018-04-01 577 0304-419X 10.1016/j.bbcan.2018.04.008 40468741 https://www.sciencedirect.com/science/article/pii/S0304419X18300064?via%3Dihub 1 b53e3c16-53b6-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28110 RAZ_Aderetti_Diana_A._2018.pdf RAZ_Aderetti_Diana_A._2018.pdf 1 CEC27B63274F8972507B3C6F81AC5498 b624d4eea1c24f0006e9369959d9466a652c550b82554e6e58652020654c159e e1430254-53b6-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28111 https://doi.org/10.1016/j.bbcan.2018.04.008 0 ea89d619-53b6-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28112 Nacionalni inštitut za biologijo 0 0 0