20.500.12556/DiRROS-20129 Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme Background Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12 to 15 months after the diagnosis. This is mostly due to therapy resistant glioblastoma stem cells in addition to intertumour heterogeneity that is due to infiltration of a plethora of host cells. Besides endothelial cells, mesenchymal stem cells and their differentiated progenies, immune cells of various differentiation states, including monocytes, comprise resident, brain tumour microenvironment. There are compelling evidence for CCL5/CCR5 in the invasive and metastatic behaviour of many cancer types. CCR5, a G-protein coupled receptor, known to function as an essential co-receptor for HIV entry, is now known to participate in driving tumour heterogeneity, the formation of cancer stem cells and the promotion of cancer invasion and metastasis. Clinical trials have recently opened targeting CCR5 using a humanized monoclonal antibody (leronlimab) for metastatic triple negative breast cancer (TNBC) or a small molecule inhibitor (maraviroc) for metastatic colon cancer. There are important CCL5 and CCR5 structure and signalling mechanisms in glioblastoma. In addition, the CCL5/CCR5 axis directs infiltration and interactions with monocytes/macrophages and mesenchymal stem cells, comprising glioblastoma stem cell niches. Conclusions CCR5 is highly expressed in glioblastoma and is associated with poor prognosis of patients. CCL5/CCR5 is suggested to be an excellent new target for glioblastoma therapy. The molecular mechanisms, by which chemoattractant and receptor respond within the complex tissue microenvironment to promote cancer stem cells and tumour heterogeneity, should be considered in forthcoming studies. cytokines CCL5-RANTES glioblastoma tumour microenvironment mesenchymal stem cells signalling true false true Angleški jezik Slovenski jezik Neznano 2024-08-06 09:06:20 2024-08-06 09:06:20 2024-08-08 03:56:14 0000-00-00 00:00:00 2019 0 0 str. 397-406, II no. 4 Vol. 53 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2019-12-01 577 1318-2099 10.2478/raon-2019-0057 5234511 RAZ_Koprivnikar_Krajnc_Miha_2019.pdf RAZ_Koprivnikar_Krajnc_Miha_2019.pdf 1 DFDF17C3D72C8C62B1B6766F88870112 ffe2acc78fac38ac0fdddab77a792cdeb92eb8d54b450fb6d874367ff740b4af d1d89b9c-53b1-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28093 https://doi.org/10.2478/raon-2019-0057 0 dd168cfd-53b1-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28094 Nacionalni inštitut za biologijo 0 0 0