20.500.12556/DiRROS-20119 Epithelial-to-mesenchymal transition as the driver of changing carcinoma and glioblastoma microenvironment Epithelial-to-mesenchymal transition (EMT) is an essential molecular and cellular process that is part of normal embryogenesis and wound healing, and also has a ubiquitous role in various types of carcinoma and glioblastoma. EMT is activated and regulated by specific microenvironmental endogenous triggers and a complex network of signalling pathways. These mostly include epigenetic events that affect protein translation-controlling factors and proteases, altogether orchestrated by the switching on and off of oncogenes and tumour-suppressor genes in cancer cells. The hallmark of cancer-linked EMT is that the process is incomplete, as it is opposed by the reverse process of mesenchymal-to-epithelial transition, which results in a hybrid epithelial/mesenchymal phenotype that shows notable cell plasticity. This is a characteristic of cancer stem cells (CSCs), and it is of the utmost importance in their niche microenvironment, where it governs CSC migratory and invasive properties, thereby creating metastatic CSCs. These cells have high resistance to therapeutic treatments, in particular in glioblastoma. carcinomas cancer stem cellsInvasion proteases tumour microenvironment rakave matične celice invazija proteaze tumorsko mikrookolje true false true Angleški jezik Slovenski jezik Neznano 2024-08-06 07:58:25 2024-08-06 07:58:26 2024-08-07 04:07:16 0000-00-00 00:00:00 2020 0 0 str. 118782, 1-14 iss. 10 Vol. 1867 Oct. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2020-10-01 577 0167-4889 10.1016/j.bbamcr.2020.118782 21291011 RAZ_Majc_Bernarda_2020.pdf RAZ_Majc_Bernarda_2020.pdf 1 7C207C2D37563E20E88955E75F634285 e2f1add117fa880c8f286a8e916bc4d9e179ff49d5bb3d800d518ecc70f1005a d576dca5-53a8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28068 https://doi.org/10.1016/j.bbamcr.2020.118782 0 e53dc69d-53a8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28069 Nacionalni inštitut za biologijo 0 0 0