20.500.12556/DiRROS-20105 Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment. angiogenesis anti-angiogenic therapy endothelial cells endothelial cell metabolism gynecological cancer non-tip cells tip cells tumor microenvironment vascular disrupting agents angiogeneza antiangiogena terapija tumorsko mikrookolje ginekološki raki true false true Angleški jezik Slovenski jezik Neznano 2024-08-05 15:51:58 2024-08-05 15:51:58 2024-08-08 03:54:43 0000-00-00 00:00:00 2021 0 0 str. 1-18 188446 iss. 1 Jan. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2021-01-01 577 0304-419X 10.1016/j.bbcan.2020.188446 35856899 RAZ_Yetkin-Arik_Bahar_2021.pdf RAZ_Yetkin-Arik_Bahar_2021.pdf 1 55B1FFCCD2678A8446B7D83A6E818B2B 5a2e0aa74ed00cb7f80885909c5efc677c408f8f1a3f1bfab35da1cfc10e5d56 ebf10be3-5321-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28028 https://doi.org/10.1016/j.bbcan.2020.188446 0 f92f9880-5321-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28029 Nacionalni inštitut za biologijo 0 0 0