20.500.12556/DiRROS-20100 Bioactive peptides from venoms against glioma progression Venoms are complex mixtures of different molecules and ions. Among them, bioactive peptides have been found to affect cancer hallmarks, such as cell proliferation, cell invasion, cell migration, and can also modulate the immune response of normal and cancer-bearing organisms. In this article, we review the mechanisms of action on these cancer cell features, focusing on bioactive peptides being developed as potential therapeutics for one of the most aggressive and deadly brain tumors, glioblastoma (GB). Novel therapeutic approaches applying bioactive peptides may contribute to multiple targeting of GB and particularly of GB stem cells. Bioactive peptides selectively target cancer cells without harming normal cells. Various molecular targets related to the effects of bioactive peptides on GB have been proposed, including ion channels, integrins, membrane phospholipids and even immunomodulatory treatment of GB. In addition to therapy, some bioactive peptides, such as disintegrins, can also be used for diagnostics or are used as labels for cytotoxic drugs to specifically target cancer cells. Given the limitations described in the last section, successful application in cancer therapy is rather low, as only 3.4% of such peptides have been included in clinical trials and have passed successfully phases I to III. Combined approaches of added bioactive peptides to standard cancer therapies need to be explored using advanced GB in vitro models such as organoids. On the other hand, new methods are also being developed to improve translation from research to practice and provide new hope for GB patients and their families. true false true Angleški jezik Ni določen Neznano 2024-08-05 14:47:21 2024-08-05 14:47:21 2024-08-08 03:54:26 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 28. 8. 2022; št. članka: 965882; str. 1-14 Vol. 12 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-08-29 577 2234-943X 10.3389/fonc.2022.965882 119389187 RAZ_Majc_Bernarda_2022.pdf RAZ_Majc_Bernarda_2022.pdf 1 8FF101987CF0E7CD97831B943526AEBF 4ba96888c0e3089f85a0f48af58ccd4df12abfd18d6223aa58b362cd82618799 9612e1a7-5318-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28015 https://doi.org/10.3389/fonc.2022.965882 0 a2df5ed7-5318-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28016 Nacionalni inštitut za biologijo 0 0 0