20.500.12556/DiRROS-20018 APS8, a polymeric alkylpyridinium salt blocks [alpha]7 nAChR and induces apoptosis in non-small cell lung carcinoma Naturally occurring 3-alkylpyridinium polymers (poly-APS) from the marine sponge Reniera sarai, consisting of monomers containing polar pyridinium and nonpolar alkyl chain moieties, have been demonstrated to exert a wide range of biological activities, including a selective cytotoxicity against non-small cell lung cancer (NSCLC) cells. APS8, an analog of poly-APS with defined alkyl chain length and molecular size, non-competitively inhibits α7 nicotinic acetylcholine receptors (nAChRs) at nanomolar concentrations that are too low to be acetylcholinesterase (AChE) inhibitory or generally cytotoxic. In the present study we show that APS8 inhibits NSCLC tumor cell growth and activates apoptotic pathways. APS8 was not toxic for normal lung fibroblasts. Furthermore, in NSCLC cells, APS8 reduced the adverse anti-apoptotic, proliferative effects of nicotine. Our results suggest that APS8 or similar compounds might be considered as lead compounds to develop antitumor therapeutic agents for at least certain types of lung cancer. 3-alkylpyridinium polymers apoptosis nicotine nicotinic acetylcholine receptor non-small cell lung carcinoma true false true Angleški jezik Ni določen Neznano 2024-08-02 10:18:26 2024-08-02 10:18:26 2024-08-03 03:45:59 0000-00-00 00:00:00 2013 0 0 Nasl. z nasl. zaslona; Opis vira z dne 20. 8. 2013; str. 2574-2594 no. 7 Vol. 11 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2013-07-16 577.1 1660-3397 10.3390/md11072574 2854223 http://www.mdpi.com/1660-3397/11/7/2574 1 0b8b17d6-5097-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27858 RAZ_Zovko_Ana_2013.pdf RAZ_Zovko_Ana_2013.pdf 1 1933F4A3AE898A003AAF96BFBE7EF34B 4e413c3c64b3e2c1e40ee50455142b838e3b3b750a6208645265ade3dc391147 cbbe3d1c-5097-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27859 https://doi.org/10.3390/md11072574 0 f24b5020-5097-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27860 Nacionalni inštitut za biologijo 0 0 0