20.500.12556/DiRROS-19823 Treatment of vulvar cancer recurrences with electrochemotherapy a detailed analysis of possible causes for unsuccessful treatment Zdravljenje ponovitve raka zunanjega spolovila z elektrokemoterapijo Background. Electrochemotherapy has good local effectiveness in the treatment of vulvar cancer. Most studies have reported the safety and effectiveness of electrochemotherapy for palliative treatment of gynecological cancers and mostly vulvar squamous cell carcinoma. Some tumors, however, fail to respond to electrochemotherapy. The biological features/determinants for the nonresponsiveness are not determined yet. Patient and methods. A recurrence of vulvar squamous cell carcinoma was treated by electrochemotherapy using intravenous administration of bleomycin. The treatment was performed by hexagonal electrodes according to standard operating procedures. We analyzed the factors that could determine nonresponsiveness to electrochemotherapy. Results. Based on the presented case of nonresponsive vulvar recurrence to electrochemotherapy, we hypothesize that the vasculature of the tumors prior to treatment may predict the response to electrochemotherapy. The histological analysis showed minimal presence of blood vessels in the tumor. Thus, low perfusion may reduce drug delivery and lead to a lower response rate because of the minor antitumor effectiveness of vascular disruption. In this case, no immune response in the tumor was elicited by electrochemotherapy. Conclusions. In this case, of nonresponsive vulvar recurrence treated by electrochemotherapy, we analyzed possible factors that could predict treatment failure. Based on histological analysis, low vascularization of the tumor was observed, which hampered drug delivery and distribution and resulted in no vascular disrupting action of electrochemotherapy. All these factors could contribute to ineffective treatment with electrochemotherapy. electrochemotherapy bleomycin vulvar cancer elektrokemoterapija bleomicin rak vulve true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-07-25 13:22:09 2024-07-25 13:22:09 2024-07-27 03:42:24 0000-00-00 00:00:00 2023 0 0 str. 121-126, XIII no. 1 Vol. 57 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-01-01 618.16:616-006 1318-2099 10.2478/raon-2023-0010 141773827 RAZ_Vivod_Gregor_2023.pdf RAZ_Vivod_Gregor_2023.pdf 1 41274BE4125B1DE8C66C806AC2E019DF bf089b206f822f0ff7e22a219bc8a439edbb68492de3436e7be6f833626a185c 8bea7290-4a67-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27484 Onkološki inštitut Ljubljana 0 0 0