20.500.12556/DiRROS-19803 Crystalloids vs. colloids for fluid optimization in patients undergoing brain tumour surgery Background. This randomised, double-blinded, single-centre study prospectively investigated the impact of goal directed therapy and fluid optimization with crystalloids or colloids on perioperative complications in patients un-dergoing brain tumour surgery. Main aim of the study was to investigate the impact of fluid type on postoperative complications.Patients and methods. 80 patients were allocated into two equal groups to be optimised with either crystalloids (n = 40) or colloids (n = 40). Invasive hemodynamic monitoring was used to adjust and maintain mean arterial pressure and cerebral oxygenation within the baseline values (± 20%) and stroke volume variation (SVV) ≤ 10%. Postoperative complications from different organ systems were monitored during the first 15 days after surgery. Hospital stay was also recorded.Results. Crystalloid group received significantly more fluids (p = 0.003) and phenylephrine (p = 0.02) compared to colloid group. This did not have any significant impact on perioperative complications and hospital stay, since no dif-ferences between groups were observed. Conclusions. Either crystalloids or colloids could be used for fluid optimization in brain tumour surgery. If protocol-ised perioperative haemodynamic management is used, the type of fluid does not have significant impact on the outcome. radiologija kirurgija možganski tumor optimizacija tekočin hemodinamika true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-07-25 09:03:17 2024-07-25 09:03:17 2024-07-26 04:28:36 0000-00-00 00:00:00 2022 0 0 str. 508-514 no. 4 Vol. 56 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 616.714.1-006:617 1318-2099 10.2478/raon-2022-0035 122082819 RAZ_Markovic_Bozic_Jasmina_2022.pdf RAZ_Markovic_Bozic_Jasmina_2022.pdf 1 77363D66C0C6EA00FE44B640528CD9F4 d3282643d325a833382621ec1c971f45f654ef4f247394840a320020dc949ba8 596c6771-4a43-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27428 Onkološki inštitut Ljubljana 0 0 0