20.500.12556/DiRROS-19801 Real-life long-term outcomes of upfront surgery in patients with resectable stage I-IIIA non-small cell lung cancer Treatment of early-stage non-small cell lung cancer (NSCLC) is rapidly evolving. When introducing novelties, real-life data on effectiveness of currently used treatment strategies are needed. The present study evaluated outcomes of stage I–IIIA NSCLC patients treated with upfront radical surgery in everyday clinical practice, between 2010–2017. Data of 539 consecutive patients were retrieved from a prospective hospital-based registry. All diagnostic, treatment and follow-up procedures were performed at the same thoracic oncology centre according to the valid guidelines. The primary outcome was overall survival (OS) analysed by clinical(c) and pathological(p) TNM (tumour, node, metastases) stage. The impact of clinicopathological characteristics on OS was evaluated using univariable (UVA) and multivariable regression analysis (MVA). With a median follow-up of 53.9 months, median OS and 5-year OS rate in the overall population were 90.4 months and 64.4%. Five-year OS rates by pTNM stage I, II and IIIA were 70.2%, 60.21%, and 49.9%, respectively. Both cTNM and pTNM stages were associated with OS; but only pTNM retained its independent prognostic value (p = 0.003) in MVA. Agreement between cTNM and pTNM was 69.0%. Next to pTNM, age (p = 0.001) and gender (p = 0.004) retained their independent prognostic value for OS. The study showed favourable outcomes of resectable stage I–IIIA NSCLC treated with upfront surgery in real-life. Relatively low agreement between cTNM and pTNM stages and independent prognostic value of only pTNM, observed in real-life data, suggest that surgery remains the most accurate provider of the anatomical stage of disease and important upfront therapy. resectable NSCLC upfront surgery real-life data overall survival prognostic factors operabilni nedrobnocelični rak pljuč preprečevalna terapija vsakodnevna klinična praksa celokupno preživetje napovedni dejavniki true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-07-25 08:59:30 2024-07-25 08:59:30 2024-07-26 04:28:35 0000-00-00 00:00:00 2022 0 0 Soavtorji: Tanja Čufer, Izidor Kern, Martina Miklavčič, Sabrina Petrovič, Vida Groznik and Aleksander Sadikov; str. 346-354 iss. 3 Vol. 56 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-01-01 616.24-006 1318-2099 10.2478/raon-2022-0030 120746499 https://sciendo.com/article/10.2478/raon-2022-0030# 1 ae3d0ef7-4a42-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27424 https://doi.org/10.2478/raon-2022-0030 1 af5518fd-4a42-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27425 RAZ_Bitenc_Marko_2022.pdf RAZ_Bitenc_Marko_2022.pdf 1 B97C05821A385CA846F661D3CA51C8F9 9506fcab36bb19f41cd4e9b7a4d4a1813b84f3776323317496c2e480d2728e59 d66fe94f-4a42-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27426 Onkološki inštitut Ljubljana 0 0 0