20.500.12556/DiRROS-19537 Chocolate and risk of chronic disease a systematic review and dose-response meta-analysis Purpose Evidence for the association between chocolate intake and risk of chronic diseases is inconclusive. Therefore, we aimed to synthesize and evaluate the credibility of evidence on the dose-response association between chocolate consumption with risk of all-cause mortality, coronary heart disease (CHD), stroke, heart failure (HF), type 2 diabetes (T2D), colorectal cancer (CRC), and hypertension. Methods Prospective studies were searched until July 2018 in PubMed, Embase, and Web of Science. Random-effects meta-analyses comparing highest versus lowest intake categories, linear, and non-linear dose-response analyses were conducted. The credibility of evidence was evaluated with the NutriGrade scoring-system. Results Overall, 27 investigations were identified (n = 2 for all-cause mortality, n = 9 for CHD, n = 8 for stroke, n = 6 for HF, n = 6 for T2D, n = 2 for hypertension and CRC, respectively). No associations with HF (RR 0.99, 95% CI 0.94, 1.04) and T2D (RR 0.94, 95% CI 0.88, 1.01) per each 10 g/day increase in chocolate intake were observed in the linear dose-response meta-analyses. However, a small inverse association for each 10 g/daily increase could be shown for the risk of CHD (RR 0.96, 95% CI 0.93, 0.99), and stroke (RR 0.90, 95% CI 0.82, 0.98). The credibility of evidence was rated either very low (all-cause mortality, HF, T2D, CRC or hypertension) or low (CHD, stroke). Conclusion Chocolate consumption is not related to risk for several chronic diseases, but could have a small inverse association with CHD and stroke. Our findings are limited by very low or low credibility of evidence, highlighting important uncertainty for chocolate–disease associations. chocolate meta-analysis dose-response credibility of evidence chronic diseases čokolada meta analize odzivi verodostojnost dokazov kronične bolezni true false true Angleški jezik Slovenski jezik Neznano 2024-07-19 03:44:12 2024-07-22 11:47:14 2024-07-23 03:55:53 0000-00-00 00:00:00 2020 0 0 Nasl. z nasl. zaslona; Opis vira z dne 21. 10. 2020; str. 389-397 1 59 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2020-02-25 577 1436-6215 10.1007/s00394-019-01914-9 33538819 https://link.springer.com/article/10.1007/s00394-019-01914-9 1 a243dc93-455f-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26938 RAZ_Morze_Jakub_2020.pdf RAZ_Morze_Jakub_2020.pdf 1 3EFBD1DF5BDFB30F16150BE66E67920D 0fc902690484c7bc7f96d4e77954037879adec9b342f80e8f2ab10cf27a64c14 ac86e60c-47fe-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=27083 Nacionalni inštitut za biologijo 0 0 0