20.500.12556/DiRROS-19464 DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases. biokemija poškodbe DNK levkociti testiranje true false true Angleški jezik Slovenski jezik Neznano 2024-07-18 03:51:16 2024-07-19 11:15:16 2024-07-20 04:03:01 0000-00-00 00:00:00 2021 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 8. 2021; Št. članka: 16793; str. 1-11 Vol. 11 18 Aug. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2021-08-18 577 2045-2322 10.1038/s41598-021-95976-7 74105859 https://www.nature.com/articles/s41598-021-95976-7 1 7884ed58-4497-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26865 RAZ_Bonassi_Stefano_2021.pdf RAZ_Bonassi_Stefano_2021.pdf 1 F83D0B9859CA0D78DDC6DA29FE7ABCF7 f776fa8ce3bbb552e77cbcc6aa5d08009005eb509ff1e278a386d58f11ce9ac9 d6a7f593-459e-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26985 Nacionalni inštitut za biologijo 0 0 0