20.500.12556/DiRROS-19435 Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia a randomized double-blind placebo-controlled trial Background Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligospermia with/without astheno- or teratozoospermia (O+-A+-T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters. Patients and methods In a randomized double-blind trial, 80 men with O+-A+-T were allocated to intervention with 16 mg astaxanthin orally daily or placebo. At baseline and after three months basic semen parameters, sperm deoxyribonucleic acid (DNA) fragmentation and mitochondrial membrane potential (MMP) of spermatozoa and serum follicle-stimulating hormone (FSH) value were measured. Results Analysis of the results of 72 patients completing the study (37 in the study group, 35 in the placebo group) did not show any statistically significant change, in the astaxanthin group no improvements in the total number of spermatozoa, concentration of spermatozoa, total motility of spermatozoa, morphology of spermatozoa, DNA fragmentation and mitochondrial membrane potential of spermatozoa or serum FSH were determined. In the placebo group, statistically significant changes in the total number and concentration of spermatozoa were determined. Conclusions The oral intake of astaxanthin did not affect any semen parameters in patients with O+-A+-T. DNA fragmentation antioxidant cancer fragmentacija DNA antioksidant rak true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-07-17 08:51:04 2024-07-17 08:51:04 2024-07-18 03:54:05 0000-00-00 00:00:00 2021 0 0 Soavtorji: Irma Virant Klun, Eda Vrtacnik Bokal, Bojana Pinter; str. 97-105, XII no. 1 Vol. 55 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2021-01-01 616-006 1318-2099 10.2478/raon-2020-0062 35757059 https://sciendo.com/article/10.2478/raon-2020-0062 1 2da2c4dc-43f8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26803 RAZ_Imamovic-Kumalic_Senka_2021.pdf RAZ_Imamovic-Kumalic_Senka_2021.pdf 1 544493E39BD79471164C242BE32B601A 61fddda62a62aac01a03344fc13a5f862522a8eec02eebd234516b1489666a58 65b22cb9-43f8-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26804 Onkološki inštitut Ljubljana 0 0 0