20.500.12556/DiRROS-19403 Tartary buckwheat flavonoids improve colon lesions and modulate gut microbiota composition in diabetic mice Tartary buckwheat flavonoids (TBFs) exhibit diverse biological activities, with antioxidant, antidiabetes, anti-inflammatory, and cholesterol-lowering properties. In this study, we investigated the role of TBFs in attenuating glucose and lipid disturbances in diabetic mice and hence preventing the occurrence of diabetes-related colon lesions in mice by regulating the gut microbiota. The results showed that TBFs (1) reversed blood glucose levels and body weight changes; (2) improved levels of serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and fasting insulin; and (3) significantly reduced diabetes-related colon lesions in diabetic mice. In addition, TBFs also affected the diabetes-related imbalance of the gut microbiota and enriched beneficial microbiota, including Akkermansia and Prevotella. The TBF also selectively increased short-chain fatty acid-producing bacteria, including Roseburia and Odoribacter, and decreased the abundance of the diabetes-related gut microbiota, including Escherichia, Mucispirillum, and Bilophila. The correlation analysis indicated that TBFs improved metabolic parameters related to key communities of the gut microbiota. Our data suggested that TBFs alleviated glucose and lipid disturbances and improved colon lesions in diabetic mice, possibly by regulating the community composition of the gut microbiota. This regulation of the gut microbiota composition may explain the observed effects of TBFs to alleviate diabetes-related symptoms. Tartary buckwheat flavonoids microbiota mice tatarska ajda flavonoidi sladkorna bolezen mikrobiota true false true Angleški jezik Slovenski jezik Neznano 2024-07-17 03:57:13 2024-07-17 10:03:48 2024-07-18 03:54:02 0000-00-00 00:00:00 2022 0 0 Article ID 4524444; str. 1-14 Vol. 2022 2022 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 2022-08-16 61:579 1741-427X 10.1155/2022/4524444 118838531 https://www.hindawi.com/journals/ecam/2022/4524444/ 1 1f4f29fd-43cf-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26767 RAZ_Cheng_Wenwen_2022.pdf RAZ_Cheng_Wenwen_2022.pdf 1 FF0A91B2B48928B0C11DDB3692AE12C3 fe5c561dc1f90321cddbe7ec1f1056ce2787d3e217366f8482d828f53d1e4fb0 8967460e-4402-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26818 Nacionalni inštitut za biologijo 0 0 0