20.500.12556/DiRROS-19321 Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charged NK cells has a potential as antitumor approach since we found their efficiency to kill patient-derived GSLCs in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients. In addition to their potent cytotoxicity, NK cells secrete IFN-γ, upregulate GSLC surface expression of CD54 and MHC class I and increase sensitivity of GSLCs to chemotherapeutic drugs. Moreover, NK cell localization in peri-vascular regions in glioblastoma tissues and their close contact with GSLCs in tumorospheres suggests their ability to infiltrate glioblastoma tumors and target GSLCs. Due to GSLC heterogeneity and plasticity in regards to their stage of differentiation personalized immunotherapeutic strategies should be designed to effectively target glioblastomas. glioblastoma natural killer cells translational oncology glioblastom naravne celice ubijalke translacijska onkologija true false true Angleški jezik Slovenski jezik Neznano 2024-07-16 03:41:52 2024-07-16 17:45:05 2024-07-17 03:59:11 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 13. 5. 2022; Ostali avtorji: Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson & Anahid Jewett; str. 1-15 Vol. 5 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2022-05-10 616-006 2399-3642 10.1038/s42003-022-03402-z 107677443 https://www.arrs.si/sl/promocija/odlicni/inc/22/odlicni-22-3.pdf 1 95df2ab9-4314-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26645 https://doi.org/10.1038/s42003-022-03402-z 1 95db7ce4-4314-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26644 RAZ_Breznik_Barbara_2022.pdf RAZ_Breznik_Barbara_2022.pdf 1 916522731EC60E747674F15A420F7970 1147744eeb7720c5cfb7bef00fa1db816d56bb98a5ff458f69ccbb0aa08d73cd bd144556-4379-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26733 Nacionalni inštitut za biologijo Institut Jožef Stefan 0 0 0