20.500.12556/DiRROS-19285 Dietary iodine intake, therapy with radioiodine, and anaplastic thyroid carcinoma Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors. The aim of the study was to determine the correlation between a higher dietary intake of iodine, frequency of ATC and the characteristics of ATC, and to find out how often patients with ATC had a history of radioiodine (RAI) therapy. Patients and methods. This retrospective study included 220 patients (152 females, 68 males; mean age 68 years) with ATC who were treated in our country from 1972 to 2017. The salt was iodinated with 10 mg of potassium iodide/ kg before 1999, and with 25 mg of potassium iodide/kg thereafter. The patients were assorted into 15-year periods: 1972%1986, 1987%2001, and 2002%2017. Results. The incidence of ATC decreased after a higher iodination of salt (p = 0.04). Patients are nowadays older (p = 0.013) and have less frequent lymph node metastases (p = 0.012). The frequency of distant metastases did not change over time. The median survival of patients in the first, second, and third periods was 3, 4, and 3 months, respectively (p < 0.05). The history of RAI therapy was present in 7.7% of patients. Conclusions. The number of patients with a history of RAI therapy did not change statistically over time. The incidence of ATC in Slovenia decreased probably because of higher salt iodination. anaplastic thyroid carcinoma iodination of salt treatment survival anaplastični rak ščitnice jodiranje soli zdravljenje preživetje true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-07-12 12:05:10 2024-07-12 12:05:10 2024-07-13 03:49:23 0000-00-00 00:00:00 2020 0 0 str. 187-193, VI no. 2 Vol. 54 Jun. 2020 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2020-06-01 616.4 1318-2099 10.2478/raon-2020-0023 14368003 https://content.sciendo.com/view/journals/raon/54/2/article-p187.xml 1 3d5b79be-4036-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26583 RAZ_Besic_Nikola_2020.pdf RAZ_Besic_Nikola_2020.pdf 1 C79A1EE56C4AA1DDD3CD13F690B8E07C 5f145a787a0c61cceec8e13b715fa2e70f3001badbc6ce665118d4a76bc17e64 700be6c9-4036-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26586 Onkološki inštitut Ljubljana 0 0 0