20.500.12556/DiRROS-19162 Helicobacter pylori treatment results in Slovenia in the period 2013-2015 as a part of European Registry on Helicobacter pylori management Background. Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in the world affecting over 50% of the world%s population. H. pylori is a grade I carcinogen, responsible for the development of 89 % of noncardia gastric cancers. In the present study we analyzed the data for H. pylori eradication treatments in Slovenia. Patients and methods. Slovenia is a part of the European Registry on Helicobacter pylori Management from the beginning. In seven medical institutions data for H. pylori eradication treatments was collected for 1774 patients from April 16th 2013 to May 15th 2016. For further modified intention to treat (mITT) analysis 1519 patients were eligible and for per protocol (PP) analysis 1346 patients. Results. Patients% dropout was 11.4%. Eradication rate for 7 day triple therapy with proton pump inhibitor (PPI) + Clarithromycin (C) + Amoxicillin (A) was 88.7% PP and 72.0% mITT; for PPI + C + Metronidazole (M) 85.2% PP and 84.4% mITT. Second line 14 day therapy PPI + A + Levofloxacin had 92.3% eradication rate PP and 87.1% mITT. Ten to fourteen day Bismuth quadruple therapy was the therapy in difficult to treat patients. At the end all patients that adhered to prescribed regimens were cured of their H. pylori infection. Conclusions. High dropout rate deserves further analysis. Slovenia is still a country with < 15% H. pylori resistance to clarithromycin, triple therapy with PPI plus two antibiotics reaches PP eradication rate > 85%, but mITT eradication rates are suboptimal. Helicobacter pylori eradication treatment European Registry on Helicobacter pylori management Slovenian results true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-07-02 13:11:54 2024-07-02 13:11:54 2024-07-03 03:39:48 0000-00-00 00:00:00 2018 0 0 Soavtorji: Marko Kastelic, Miroslav Vujasinovic, Polona Lampic, Maja Seruga, Natasa Brglez Jurecic, Olga P. Nyssen, Maria G. Donday, Colm O'Morain, Francis Megraud, Adrian G McNicholl, Javier P. Gisbert; str. 1-6, I no. 1 Vol. 52 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2018-01-01 616.3 1318-2099 10.1515/raon-2017-0055 93860353 RAZ_Tepes_Bojan_2018.pdf RAZ_Tepes_Bojan_2018.pdf 1 725283A5947443F775708DE9990057FC 09a231d7d141eba21bc092ac8d39d47684591f78b61665e89422a963872a2ac4 0768f6d4-3864-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26380 Onkološki inštitut Ljubljana 0 0 0