20.500.12556/DiRROS-19117 New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. aerobic glycolysis anaerobic glycolysis angiogenesis ATP synthesis cancer cells cancer stem cells endothelial cells energy metabolism eye diseases oxidative phosphorylation pericytes retina Warburg effect rak onkologija rakave celice bolezni oči metabolizem angiogeneza true false true Angleški jezik Slovenski jezik Neznano 2024-06-18 16:46:32 2024-06-18 16:46:33 2024-06-19 03:38:12 0000-00-00 00:00:00 2024 0 0 Soavtorji: Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, S. Katrin Galun, Miloš Vittori, Mateja Erdani Kreft, Metka Novak, Barbara Breznik, and Vashendriya V.V. Hira; str. 329-352 iss. 5 Vol. 72 Mai 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2024-05-01 576 0022-1554 10.1369/00221554241249515 199290115 https://doi.org/10.1369/00221554241249515 1 90972dd5-2d81-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26305 RAZ_Noorden_Cornelis_J._F._van_2024.pdf RAZ_Noorden_Cornelis_J._F._van_2024.pdf 1 31C5087AE9BFCAD3C92294006360F688 62b62562aa824e7af204cfeed9bce894a7ed6727ebec8e18ce8da2963888c437 ec0f511b-2d81-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26306 Nacionalni inštitut za biologijo 0 0 0