20.500.12556/DiRROS-19098 Stress knowledge map a knowledge graph resource for systems biology analysis of plant stress responses Stress Knowledge Map (SKM; https://skm.nib.si) is a publicly available resource containing two complementary knowledge graphs that describe the current knowledge of biochemical, signaling, and regulatory molecular interactions in plants: a highly curated model of plant stress signaling (PSS; 543 reactions) and a large comprehensive knowledge network (488 390 interactions). Both were constructed by domain experts through systematic curation of diverse literature and database resources. SKM provides a single entry point for investigations of plant stress response and related growth trade-offs, as well as interactive explorations of current knowledge. PSS is also formulated as a qualitative and quantitative model for systems biology and thus represents a starting point for a plant digital twin. Here, we describe the features of SKM and show, through two case studies, how it can be used for complex analyses, including systematic hypothesis generation and design of validation experiments, or to gain new insights into experimental observations in plant biology. Stress knowledge map knowledge graph knowledge network entry point plant digital twin plant stress responses plant signaling systems biology SKM graf znanja mreža znanja vstopna točka digitalni dvojček rastline odzivi rastlin na stres signalizacija rastlin sistemska biologija true false true Angleški jezik Slovenski jezik Neznano 2024-06-11 14:45:17 2024-06-11 14:45:18 2024-09-09 15:12:54 0000-00-00 00:00:00 2024 0 0 Soavtorji: Živa Ramšak, Andras Bittner, Vid Podpečan, Maja Zagorščak, Bernhard Wurzinger, Špela Baebler, Marko Petek, Maja Križnik, Annelotte van Dieren, Juliane Gruber, Leila Afjehi-Sadat, Wolfram Weckwerth, Anže Županič, Markus Teige, Ute C. Vothknecht and Kristina Gruden; Nasl. z nasl. zaslona; Opis vira z dne 11. 6. 2024; str. 1-15 [art. no.] ǂ100920 iss. 6 10 Jun. 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2024-06-10 577.2 2590-3462 10.1016/j.xplc.2024.100920 198383363 https://skm.nib.si 1 786c958a-27f0-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26263 https://doi.org/10.1016/j.xplc.2024.100920 1 7828bf39-27f0-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26262 RAZ_Bleker_Carissa_2024.pdf RAZ_Bleker_Carissa_2024.pdf 1 E411194F1EC267F27BE12CD3DB83A435 1a0f21e08afe67234d12986dcfd1f08cbb30258f4116d08fb342f5f33e54e1e6 eb1a88b9-27f0-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26266 Nacionalni inštitut za biologijo 0 0 0