20.500.12556/DiRROS-19082 Induction chemotherapy, chemoradiotherapy and consolidation chemotherapy in preoperative treatment of rectal cancer long-term results of phase II OIGIT-01 Trial The purpose of the study was to improve treatment efficacy for locally advanced rectal cancer (LARC) by shifting half of adjuvant chemotherapy preoperatively to one induction and two consolidation cycles. Patients and methods Between October 2011 and April 2013, 66 patients with LARC were treated with one induction chemotherapy cycle followed by chemoradiotherapy (CRT), two consolidation cycles, surgery and three adjuvant capecitabine cycles. Radiation doses were 50.4 Gy for T2-3 and 54 Gy for T4 tumours in 1.8 Gy daily fraction. The doses of concomitant and neo/adjuvant capecitabine were 825 mg/m2/12h and 1250mg/m2/12h, respectively. The primary endpoint was pathologic complete response (pCR). Results Forty-three (65.1%) patients were treated according to protocol. The compliance rates for induction, consolidation, and adjuvant chemotherapy were 98.5%, 93.8% and 87.3%, respectively. CRT was completed by 65/66 patients, with G % 3 non-hematologic toxicity at 13.6%. The rate of pCR (17.5%) was not increased, but N and the total-down staging rates were 77.7% and 79.3%, respectively. In a median follow-up of 55 months, we recorded one local relapse (LR) (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates were 64.0% (95% CI 63.89%64.11) and 69.5% (95% CI 69.39%69.61), respectively. Conclusions In LARC preoperative treatment intensification with capecitabine before and after radiotherapy is well tolerated, with a high compliance rate and acceptable toxicity. Though it does not improve the local effect, it achieves a high LR rate, DFS, and OS. rectal cancer neoadjuvant chemotherapy preoperative chemoradiotherapy rak danke neoadjuvantna kemoterapija predoperativna kemoradioterapija true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-06-11 08:42:51 2024-06-11 08:42:51 2024-06-12 03:43:40 0000-00-00 00:00:00 2018 0 0 str. 267-274, III no. 3 Vol. 52 Sep. 2018 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2018-09-01 616.3 1318-2099 3025275 https://content.sciendo.com/view/journals/raon/52/3/article-p267.xml 1 d491989a-27bd-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26235 RAZ_Golo_Danijela_2018.pdf RAZ_Golo_Danijela_2018.pdf 1 9F846E2FCD30FE029C03B1EDDC17A28B d9e05bdf331753a4d8c9deedc55b32b16627f6457343ab9d3210ee6dd5cf0dc8 fe06264e-27bd-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26236 Onkološki inštitut Ljubljana 0 0 0