20.500.12556/DiRROS-19035 Exploring BPA alternatives environmental levels and toxicity review Exploring BPA alternatives – environmental levels and toxicity review Bisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol A (BPA) that offer similar functionality. These alternatives are already in the market, entering the environment and thus raising ecological concerns. However, it can be expected that levels of BPA alternatives will dominate in the future, they are limited information on their environmental safety. The EU PARC project highlights BPA alternatives as priority chemicals and consolidates information on BPA alternatives, with a focus on environmental relevance and on the identification of the research gaps. The review highlighted aspects and future perspectives. In brief, an extension of environmental monitoring is crucial, extending it to cover BPA alternatives to track their levels and facilitate the timely implementation of mitigation measures. The biological activity has been studied for BPA alternatives, but in a non-systematic way and prioritized a limited number of chemicals. For several BPA alternatives, the data has already provided substantial evidence regarding their potential harm to the environment. We stress the importance of conducting more comprehensive assessments that go beyond the traditional reproductive studies and focus on overlooked relevant endpoints. Future research should also consider mixture effects, realistic environmental concentrations, and the long-term consequences on biota and ecosystems. BPA alternatives biological activity in silico invertebrates vertebrates toxicity BPA alternative biološka aktivnost in silico nevretenčarji vretenčarji toksičnost true false true Angleški jezik Slovenski jezik Neznano 2024-06-03 11:16:51 2024-06-03 11:16:51 2024-09-06 03:45:15 0000-00-00 00:00:00 2024 0 0 Soavtorji: Ksenia J. Groh, Anna Białk-Bielińska, Beate I. Escher, R. Beaudouin, L. Mora Lagares, K.E. Tollefsen, Martina Fenske, Ewa Mulkiewicz, Nicolas Creusot, Anita Sosnowska, Susana Loureiro, Jonny Beyer, Guillermo Repetto, Alja Štern, Isabel Lopes, Marta Monteiro, Andrea Zikova-Kloas, Tina Eleršek, Marjan Vračko, Szymon Zdybel, Tomasz Puzyn, Weronika Koczur, Jane Ebsen Morthorst, Henrik Holbec, Gunnar Carlsson, Stefan Örn, Óscar Herrero, Ayesha Siddique, Matthias Liess, Georg Braun, Vanessa Srebny, Bojana Žegura, Nathalie Hinfray, François Brion et al.; Online first: 23 May 2024; Članek v PDF formatu obsega 72 str.; 2024 0000-00-00 PostprintKoncna VTisku apc 0000-00-00 0000-00-00 2024-05-23 615.9 0160-4120 10.1016/j.envint.2024.108728 197535491 https://doi.org/10.1016/j.envint.2024.108728 1 06266430-218a-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26127 RAZ_Adamovsky_Ondrej_2024.pdf RAZ_Adamovsky_Ondrej_2024.pdf 1 76D7CA4A1A8A7F9D6D1C0E456799A8E0 25f6eb6fdde4262643786e50593055916ff4f70bea2d4f0516f4586ee1b80e00 70b3938f-218b-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26128 RAZ_Adamovsky_Ondrej_2024.pdf RAZ_Adamovsky_Ondrej_2024.pdf 1 0DB1D0F9ABC465BEF93B53E3BD6DE885 2e18f7ca71ef4df1abe6db3d24590345904e5f4907a0280861aa537225ea2c82 b5e0b0e7-6b5c-11ef-b487-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=28670 Nacionalni inštitut za biologijo 0 0 0