20.500.12556/DiRROS-19034 Dynamic susceptibility contrast enhanced (DSC) MRI perfusion and plasma cytokine levels in patients after tonic-clonic seizures Background Inflammatory events in brain parenchyma and glial tissue are involved in epileptogenesis. Blood concentration of cytokines is shown to be elevated after tonic-clonic seizures. As a result of inflammation, blood-brain barrier leakage occurs. This can be documented by imaging techniques, such is dynamic susceptibility contrast enhanced (DSC) MRI perfusion. Our aim was to check for postictal brain inflammation by studying DSC MRI perfusion and plasma level of cytokines. We looked for correlations between number and type of introducing seizures, postictal plasma level of cytokines and parameters of DSC MRI perfusion. Furthermore, we looked for correlation of those parameters and course of the disease over one year follow up. Patients and methods We prospectively enrolled 30 patients, 8%24 hours after single or repeated tonic-clonic seizures. Results 25 of them had normal perfusion parameters, while 5 had hyperperfusion. Patients with hyperperfusion were tested again, 3 months later. Two of 5 had hyperperfusion also on control measurements. Number of index seizures negatively correlated with concentration of proinflammatory cytokines IL-10, IFN-[gamma] and TNF-[alpha] in a whole cohort. In patients with hyperperfusion, there were significantly lower concentrations of antiinflammatory cytokine IL-4 and higher concentrations of proinflammatory TNF-[alpha]. Conclusions Long lasting blood- brain barrier disruption may be crucial for epileptogenesis in selected patients. cytokines blood-brain barrier tonic-clonic seizures citokini krvno-možganska pregrada tonično-klonični napadi true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-06-03 11:12:58 2024-06-03 11:12:58 2024-06-04 03:38:30 0000-00-00 00:00:00 2017 0 0 Soavtorji: Katarina Surlan Popovic, Alojz Ihan, David Bozidar Vodusek; str. 277-285, IV no. 3 Vol. 51 Sep. 2017 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2017-09-01 616.8 1318-2099 10.1515/raon.2017.0031 33377753 https://www.degruyter.com/view/j/raon.ahead-of-print/raon-2017-0031/raon-2017-0031.xml?format=INT 1 79204c37-2189-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26124 RAZ_Filipovic_Tatjana_2017.pdf RAZ_Filipovic_Tatjana_2017.pdf 1 399DB82E770D109DF7C21F5736647CA4 1faa4cdcc5caabba9f8f1044971192dcb2630921c5011f65f4204cd71fc4832b ad3ba399-2189-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=26125 Onkološki inštitut Ljubljana 0 0 0