20.500.12556/DiRROS-18906 Primary pulmonary choricarcinoma The aim of the study was to establish whether there are different clinical entities of primary pulmonary choriocarcinoma (PPC) that deserve different diagnostic approach and the most optimal treatment. Patients and methods. A systematic review with PubMed search was conducted to identify studies that reported cases of PPC. The eligibility criteria were histological diagnosis of pulmonary choriocarcinoma and thorough examination of the reproductive organs to exclude potential primary choriocarcinoma in the gonads. Furthermore, to illustrate the review we additionally present a patient referred at our institution. Results. 55 cases (17 men) were included in the review with a median age of 34 years. Women with the history of gestational event showed better survival outcome than women without the history of gestational event. Patients treated with combined modality treatment (surgery and chemotherapy) survived longer than the patients without combined modality treatment. Furthermore, multivariate analysis of prognostic factors showed that the combined modality treatment had independent prognostic significance. Size of the tumour showed significant prognostic influence in univariate and multivariate analysis. Conclusions. PPC is an extreme rarity with variable clinical characteristics and outcome. It is important to capture and treat patients in the early stages of the disease. Women with the history of gestational event may show better survival, therefore genetic examination could help us to predict patient%s prognosis. Surgery followed by adjuvant chemotherapy appears to represent the best treatment for PPC. choriocarcinoma gestational event pulmonary tumor primary horiokarcinom horiokarcinom nosečnost rak pljuč primarni horiokarcinom true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-05-10 14:11:04 2024-05-10 14:11:04 2024-05-11 03:34:59 0000-00-00 00:00:00 2017 0 0 str. 1-7, I no. 1 Vol. 51 2017 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2017-01-01 616-006 1318-2099 10.1515/raon-2016-0038 2345595 RAZ_Snoj_Ziga_2017.pdf RAZ_Snoj_Ziga_2017.pdf 1 279F0F38341F9FDA74B3ADB0B8A746A3 d4adbccbb71ae1ec9e5fa0a67c99d5a270ef48166a72e81780173892ff6ba20a 952f65be-0ec6-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25894 Onkološki inštitut Ljubljana 0 0 0