20.500.12556/DiRROS-18898 Red blood cell transfusion and skeletal muscle tissue oxygenation in anaemic haematologic outpatients Background. Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. Patients and methods. Twenty-four chronic anaemic haematology patients were included. Thenar skeletal muscle StO2 was measured at rest (basal StO2), with vascular occlusion testing (upslope StO2, maximum StO2) before and after transfusion. Results. Basal StO2 was low (53% +- 7%). Average RBC storage time was 10.5 +- 3.9 days. Effects of RBC transfusions were as follows: basal StO2 and upslope StO2 did not change significantly; maximum StO2 increased compared to baseline (64 +- 14% vs. 59 +- 10%, p = 0.049). Change of basal StO2, upslope StO2 and maximum StO2 was negatively related to age of RBCs. The decrease of maximum StO2 was predicted (sensitivity 70%, specificity 100%), after receiving RBCs >- 10days old. Discussion. Resting skeletal muscle StO2 in chronic anaemic patients is low. RBC storage time affects skeletal muscle StO2 in the resting period and after ischaemic provocation. skeletal muscle transfusion red blood cells skeletne mišice oksigenacija transfuzija eritrociti true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-05-09 14:17:18 2024-05-09 14:17:18 2024-05-10 03:36:25 0000-00-00 00:00:00 2016 0 0 Soavtorji: Ana Ursula Gavric, Eva Podbregar, Hugon Mozina, Sebastian Stefanovic; str. 449-455, X no. 4 Vol. 50 Dec. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2016-12-01 615.38:616.155.1 1318-2099 10.1515/raon-2015-0046 32508889 http://www.degruyter.com/view/j/raon.ahead-of-print/raon-2015-0046/raon-2015-0046.xml 1 14ffd7d4-0dfe-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25880 RAZ_Podbregar_Matej_2016.pdf RAZ_Podbregar_Matej_2016.pdf 1 C501C910C0DEA689423DB8F27900ABED e71caae21afa69f0bdac60a15aee40ee4ce27f033e59686b997c6c8b40bd7d0b 3eaab6e3-0dfe-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25881 Onkološki inštitut Ljubljana 0 0 0