20.500.12556/DiRROS-18895 Prognostic factors of choroidal melanoma in Slovenia, 1986-2008 Introduction. Choroidal melanoma is the most common primary malignancy of the eye, which frequently metastasizes. The Cancer Registry of Slovenia reported the incidence of choroid melanoma from 1983 to 2009 as stable, at 7.8 cases/million for men and 7.4/million for women. The aim of the retrospective study was to determinate the prognostic factors of survival for choroidal melanoma patients in Slovenia. Patients and methods. From January 1986 to December 2008 we treated 288 patients with malignant choroidal melanoma; 127 patients were treated by brachytherapy with beta rays emitting ruthenium-106 applicators; 161 patients were treated by enucleation. Results. Patients with tumours thickness < 7.2 mm and base diameter < 16 mm were treated by brachytherapy and had 5- and 10-year overall mortality 13% and 32%, respectively. In enucleated patients, 5- and 10-year mortality was higher, 46% and 69%, respectively, because their tumours were larger. Thirty patients treated by brachytherapy developed local recurrence. Twenty five of 127 patients treated by brachytherapy and 86 of 161 enucleated patients developed distant metastases. Patients of age >/= 60 years had significantly lower survival in both treatment modalities. For patients treated by brachytherapy the diameter of the tumour base and treatment time were independent prognostic factors for overall survival, for patients treated by enucleation age and histological type of tumour were independent prognosticators. In first few years after either of treatments, the melanoma specific annual mortality rate increased, especially in older patients, and then slowly decreased. Conclusions. It seems that particularly younger patients with early tumours can be cured, whereby preference should be given to eyesight preserving brachytherapy over enucleation. choroidal melanoma therapy brachytherapy prognostic factors melanom žilnica terapija brahiterapija napovedni dejavniki true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-05-09 13:49:17 2024-05-09 13:49:17 2024-05-10 03:36:25 0000-00-00 00:00:00 2016 0 0 Soavtorji: Marjan Budihna, Brigita Drnovsek-Olup, Katrina Novak Andrejcic, Irena Brovet Zupancic, Dusica Pahor; str. 104-112, VII no. 1 Vol. 50 Mar. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2016-03-01 617.721.6-006 1318-2099 10.1515/raon-2015-0009 31864281 http://ojs.szd.si/index.php/ro/article/view/2300/1845 1 2abceba3-0dfa-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25874 RAZ_Jancar_Boris_2016.pdf RAZ_Jancar_Boris_2016.pdf 1 FD85B97C2DB5DB97F6F870E5285ECE0B ec962cbe7e989b3050de1f417f1463befdee3d9ad89d115fc566ced49c15b679 5d61fbba-0dfa-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25875 Onkološki inštitut Ljubljana 0 0 0