20.500.12556/DiRROS-18890 CA19-9 serum levels predict micrometastases in patients with gastric cancer Background. We explored the prognostic value of the up-regulated carbohydrate antigen (CA19-9) in node-negative patients with gastric cancer as a surrogate marker for micrometastases. Patients and methods. Micrometastases were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for a subgroup of 30 node-negative patients. This group was used to determine the cut-off for preoperative CA19-9 serum levels as a surrogate marker for micrometastases. Then 187 node-negative T1 to T4 patients were selected to validate the predictive value of this CA19-9 threshold. Results. Patients with micrometastases had significantly higher preoperative CA19-9 serum levels compared to patients without micrometastases (p = 0.046). CA19-9 serum levels were significantly correlated with tumour site, tumour diameter, and perineural invasion. Although not reaching significance, subgroup analysis showed better five-year survival rates for patients with CA19-9 serum levels below the threshold, compared to patients with CA19-9 serum levels above the cut-off. The cumulative survival for T2 to T4 node-negative patients was significantly better with CA19-9 serum levels below the cut-off (p = 0.04). Conclusions. Preoperative CA19-9 serum levels can be used to predict higher risk for haematogenous spread and micrometastases in node-negative patients. However, CA19-9 serum levels lack the necessary sensitivity and specificity to reliably predict micrometastases. gastric cancer micrometastases CA19-9 rak (medicina) želodec metastaze diagnostika antigeni tumorski označevalci true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-05-09 13:33:10 2024-05-09 13:33:10 2024-05-10 03:36:25 0000-00-00 00:00:00 2016 0 0 Soavtorji: Stojan Potrc, Katarina Mis, Mojca Plankl, Tomaz Mars; str. 204-211, VI no. 2 Vol. 50 Jun. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2016-06-01 616.3-006-07 1318-2099 10.1515/raon-2015-0025 5741375 http://ojs.szd.si/index.php/ro/article/view/2257/1872 1 ea38a6ac-0df7-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25865 RAZ_Jagric_Tomaz_2016.pdf RAZ_Jagric_Tomaz_2016.pdf 1 7C8AAB04CB52B9FAE01DE7B978E682B6 e7fe23767b0da6447df01a075c56279578bc66dc21a26d0a5791b2eba1073db2 14f5b227-0df8-11ef-9c9e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25866 Onkološki inštitut Ljubljana 0 0 0