20.500.12556/DiRROS-18868 Uncertainties in target volume delineation in radiotherapy are they relevant and what can we do about them? Modern radiotherapy techniques enable delivery of high doses to the target volume without escalating dose to organs at risk, offering the possibility of better local control while preserving good quality of life. Uncertainties in target volume delineation have been demonstrated for most tumour sites, and various studies indicate that inconsistencies in target volume delineation may be larger than errors in all other steps of the treatment planning and delivery process. The aim of this paper is to summarize the degree of delineation uncertainties for different tumour sites reported in the literature and review the effect of strategies to minimize them. Conclusions. Our review confirmed that interobserver variability in target volume contouring represents the largest uncertainty in the process for most tumour sites, potentially resulting in a systematic error in dose delivery, which could influence local control in individual patients. For most tumour sites the optimal combination of imaging modalities for target delineation still needs to be determined. Strict use of delineation guidelines and protocols is advisable both in every day clinical practice and in clinical studies to diminish interobserver variability. Continuing medical education of radiation oncologists cannot be overemphasized, intensive formal training on interpretation of sectional imaging should be included in the program for radiation oncology residents. target volume interobserver variability delineation uncertainties imaging radioterapija obsevanje tarčni volumni vrisovanje razlike zmanjševanje neujemanja true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-30 12:49:28 2024-04-30 12:49:28 2024-05-01 03:58:16 0000-00-00 00:00:00 2016 0 0 str. 254-262, I no. 3 Vol. 50 Sep. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2016-09-01 615.849 1318-2099 10.1515/raon-2016-0023 2488955 https://www.degruyter.com/downloadpdf/j/raon.2016.50.issue-3/raon-2016-0023/raon-2016-0023.xml 1 5204f7f9-06df-11ef-a26d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25829 RAZ_Segedin_Barbara_2016.pdf RAZ_Segedin_Barbara_2016.pdf 1 8832F1D22DDB6F06E217DB56EA1F9E41 a892da375b555dd0f4316a763127ac31890c0e2e1866b0c52288431c8fa473fb 09ca28f6-06e1-11ef-a26d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25830 Onkološki inštitut Ljubljana 0 0 0