20.500.12556/DiRROS-18859 The impact of anaemia on treatment outcome in patients with squamous cell carcinoma of anal canal and anal margin Radiochemotherapy is the main treatment for patients with squamous cell carcinoma of the anal canal. Anaemia is reported to have adverse effect on survival in cancer patients. The aim of the study was to evaluate the influence of anaemia on radiochemotherapy treatment outcome in patients with squamous cell carcinoma of the anal canal. Patients and methods. One hundred consecutive patients with histologically confirmed squamous cell carcinoma of the anal canal were treated radically with 3-dimensional conformal or intensity-modulated radiation therapy followed by brachytherapy or external beam radiotherapy boost and with concurrent mitomycin C and 5-fluorouracil. The influence on survival of pre-treatment, mean on-treatment and end-of-treatment haemoglobin (Hb) concentrations was studied. Results. The 5-year locoregional control, disease free survival, disease specific survival and overall survival rates for all patients were 72%, 71%, 77% and 62%, respectively. In univariate analysis, patients with pre-treatment and end-oftreatment Hb > 120 g/L survived statistically significantly better compared to patients with Hb % 120 g/L. Patients with mean on-treatment Hb > 120 g/L only had statistically significant better locoregional control and overall survival than patients with Hb % 120 g/L. In multivariate analysis, independent prognostic factors were pre-treatment Hb (> 120 g/L vs. % 120 g/L) for overall survival (hazard ratio [HR] = 0.419, 95% confidence interval [CI] = 0.190%0.927, p = 0.032) and stage (I & II vs. III) for disease specific (HR = 3.523, 95% CI = 1.375%9.026, p = 0.009) and overall survival (HR = 2.230, 95% CI = 1.167%4.264, p = 0.015). Conclusions. The pre-treatment, mean on-treatment and end-of-treatment Hb concentration > 120 g/L carried better prognosis for patients for with squamous cell carcinoma of the anal canal treated with radiochemotherapy. The pre-treatment Hb > 120 g/L was an independent prognostic factor for overall survival of patients with anal canal cancer. anaemia anal canal squamous cell carcinoma radiochemotherapy anemija ploščatocelični analni kanal radiokemoterapija true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-30 12:18:59 2024-04-30 12:18:59 2024-05-01 03:58:15 0000-00-00 00:00:00 2016 0 0 str. 113-120, VIII no. 1 Vol. 50 Mar. 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2016-03-01 616-006 1318-2099 10.1515/raon-2015-0015 2275963 http://www.degruyter.com/view/j/raon.2016.50.issue-1/raon-2015-0015/raon-2015-0015.xml?format=INT 1 0fd99b09-06db-11ef-a26d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25817 RAZ_Oblak_Irena_2016.pdf RAZ_Oblak_Irena_2016.pdf 1 5B54E9EA8B76C6B875137A1A69E0096C 4c0acca1f419596990ae2221f18e8a63772adabe0afebb0e04bc32b5a809b8d8 3616f622-06db-11ef-a26d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25818 Onkološki inštitut Ljubljana 0 0 0