20.500.12556/DiRROS-18797 Gamma-enolase a well known tumour marker, with a less-known role in cancer Gama-enolaza. Dobro poznan tumorski označevalec, z manj poznano vlogo pri raku Gamma-enolase, known also as neuron-specific enolase (NSE), is an enzyme of the glycolytic pathway, which is expressed predominantly in neurons and cells of the neuroendocrine system. As a tumour marker it is used in diagnosis and prognosis of cancer; however, the mechanisms enrolling it in malignant progression remain elusive. As a cytoplasmic enzyme gamma-enolase is involved in increased aerobic glycolysis, the main source of energy in cancer cells, supporting cell proliferation. However, different cellular localisation at pathophysiological conditions, proposes other cellular engagements. The C-terminal part of the molecule, which is not related to glycolytic pathway, was shown to promote survival of neuronal cells by regulating neuronal growth factor receptor dependent signalling pathways, resulting also in extensive actin cytoskeleton remodelling. This additional function could be important also in cancer cells either to protect cells from stressful conditions and therapeutic agents or to promote tumour cell migration and invasion. Gamma-enolase might therefore have a multifunctional role in cancer progression: it supports increased tumour cell metabolic demands, protects tumour cells from stressful conditions and promotes their invasion and migration. gamma-enolase cancer glycolysis cell survival tumour marker true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-23 06:07:51 2024-04-23 06:07:52 2024-04-24 03:39:26 0000-00-00 00:00:00 2015 0 0 str. 217-226 no. 3 Vol. 49 Sep. 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2015-09-01 616-006 1318-2099 10.515/raon-2015-0035 3908721 http://www.degruyter.com/view/j/raon.2015.49.issue-3/raon-2015-0035/raon-2015-0035.xml?format=INT 1 0eaa3843-0127-11ef-b1b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25714 RAZ_Vizin_Tjasa_2015.pdf RAZ_Vizin_Tjasa_2015.pdf 1 DE3B99A16E3A229F3FDF3908BBB5B31B 3ea3cc04dfa22c1cad85154eac184f04a0ea27442389e0453a68d7d208cb204f f916a0fa-012b-11ef-b1b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25715 Onkološki inštitut Ljubljana 0 0 0