20.500.12556/DiRROS-18791 Prognostic value of some tumor markers in unresectable stage IV oropharyngeal carcinoma patients treated with concomitant radiochemotherapy The aim of the study was to investigate how the expression of tumor markers p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31 influenced the outcome of advanced inoperable oropharyngeal carcinoma patients, treated with concomitant radiochemotherapy. Patients and methods. The pretreatment biopsy specimens of 74 consecutive patients with inoperable stage IV oropharyngeal squamous cell carcinoma treated with concomitant radiochemotherapy were in retrospective study processed by immunochemistry for p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31. Disease-free survival (DFS) was assessed according to the expression of tumor markers. Results. Patients with a high expression of p21 (%10%), p27 (>50%), Ki-67 (>50%), CD31 (>130 vessels/mm2) and low expression of p53 (<10%), cyclin D1 (<10%) and EGFR (<10%) (favorable levels - FL) had better DFS than patients with a low expression of p21 (<10%), p27 (%50%), Ki-67 (%50%), CD31 (<130 vessels/mm2) and high expression of p53 (%10%), cyclin D1 (%10%) and EGFR (%10%) (unfavorable levels - UL). However, statistical significance in survival between FL and UL was achieved only for p27 and cyclin D1. DFS significantly decreased with an increasing number of markers with an unfavorable level per tumor (1%4 vs. 5%7) (78% vs. 32%, respectively; p = 0.004). The number of markers per tumor with UL of expression retained prognostic significance also in multivariate analysis. Conclusions. Statistical significance in survival between FL and UL emerged only for p27 and cyclin D1. The number of markers per tumor with UL of expression was an independent prognostic factor for an adverse outcome . oropharynx radiochemotherapy tumor markers ustno žrelo tumorji radiokemoterapija tumorski označevalci true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-22 14:37:12 2024-04-22 14:37:12 2024-04-24 03:39:26 0000-00-00 00:00:00 2015 0 0 str. 365-370, IV no. 4 Vol. 49 Dec. 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2015-12-01 616.21-006 1318-2099 10.2478/raon-2014-0048 2215035 RAZ_Soba_Erika_2015.pdf RAZ_Soba_Erika_2015.pdf 1 8E70FF0769382822F55D4A213E267C80 ec5cf58a102ff6910e474931c069e64162d707b85ad4edbaf41e16c3f5ade6f4 35d48901-00a5-11ef-ab10-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25706 Onkološki inštitut Ljubljana 0 0 0