20.500.12556/DiRROS-18728 Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer correlation with traditional prognostic factors Background. Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients. The purpose of this study was to evaluate the correlation between traditional prognostic factors and uPA and PAI-1 expression in primary tumour of breast cancer patients. Patients and methods. 606 primary breast cancer patients were enrolled in the prospective study in the Department of gynaecological oncology and breast oncology at the University Medical Centre Maribor between the years 2004 and 2010. We evaluated the traditional prognostic factors (age, menopausal status, tumour size, pathohistological type, histologic grade, lymph node status, lymphovascular invasion and hormone receptor status), together with uPA and PAI-1. We used Spearman%s rank correlation, Mann Whitney U test and X2 test for statistical analysis. Results. Our findings indicate a positive correlation between uPA and tumour size (p < 0.001), grade (p < 0.001), histological type (p < 0.001), lymphovascular invasion (p = 0.01) and a negative correlation between uPA and hormone receptor status (p < 0.001). They also indicate a positive correlation between PAI-1 and tumour size (p = 0.004), grade (p < 0.001), pathohistological type (p < 0.001) and negative correlation between PAI-1 and hormone receptor status (p = 0.002). Conclusions. Our study showed a relationship between uPA and PAI-1 and traditional prognostic factors. Their role as prognostic and predictive factors remains to be further evaluated. urokinase plasminogen activator plasminogen activator inhibitor breast cancer dojke rak (medicina) urokinaza aktivator plazminogena plazminogen true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-17 14:18:18 2024-04-17 14:18:18 2024-04-18 03:46:11 0000-00-00 00:00:00 2015 0 0 str. 357-364, IV no. 4 Vol. 49 Dec. 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2015-12-01 618.19-006 1318-2099 10.2478/raon-2014-0049 1979259 http://www.degruyter.com/view/j/raon.ahead-of-print/raon-2014-0049/raon-2014-0049.xml?format=INT 1 cc977f71-fca3-11ee-ae20-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25615 RAZ_Lampelj_Maja_2015.pdf RAZ_Lampelj_Maja_2015.pdf 1 D89A179898763D1F7B9C795AF15503D7 0e3a9ed148294705eae8bf7ae5c438fb19b9c9ca0499ccbd8ba564a8ebc810dd 064a0597-fca4-11ee-ae20-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25616 Onkološki inštitut Ljubljana 0 0 0