20.500.12556/DiRROS-18691 Circulating serum sVCAM-1 concentration inadvanced ovarian cancer patients correlation with concentration in ascites Background. Vascular cell adhesion molecule-1 (VCAM-1) is associated with ovarian cancer progression but theorigin of its soluble form (sVCAM-1) in serum is not well investigated. The purpose of this study was to elucidate whetherthe concentration of sVCAM-1 in serum correlates with the concentration in ascites, that represents local tumour environment,and with systemic inflammation, various clinicopathological characteristics, and patient outcome.Patients and methods. Thirty-six patients with advanced ovarian cancer were included in the study. Serum forsVCAM-1 analysis was obtained prior to surgery. Ascites samples were collected at the beginning of the operation.Clinical data were collected from patients medical records. sVCAM-1 in samples was analysed by flow cytometricbead-based assay. The mean follow-up period was 11 months (range 0-23) from the time of surgery.Results. Serum sVCAM-1 concentrations are positively correlated to ascites sVCAM-1 concentrations. There was aweakly positive correlation of serum sVCAM-1 with tumour size and no correlation with inflammatory tumour markers,FIGO stage or grade. Higher concentrations of sVCAM-1 were associated with poor disease outcome (death fromovarian cancer) in almost all cases before chemotherapy was started.Conclusion. This is the first study demonstrating that serum concentrations of sVCAM-1 in advanced ovarian cancerpatients correlate with sVCAM-1 concentrations in ascites, thus expressing the biologic potential of malignant diseaseto metastasis, rather than systemic inflammation. Higher serum and ascites sVCAM-1 concentrations might have predictivepotential for different biologic behaviour. ginekologija tumorji sVCAM-1 true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-16 10:17:20 2024-04-16 10:17:21 2024-04-17 03:46:24 0000-00-00 00:00:00 2014 0 0 Soavtorji: Katarina Cerne, Ivan Verdenik, Borut Kobal; str. 307-313, VI iss. 3 Vol. 48 Sep. 2014 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2014-09-01 616-006 1318-2099 10.2478/raon-2013-0066 30924505 RAZ_Jakimovska_Marina_2014.pdf RAZ_Jakimovska_Marina_2014.pdf 1 34DAC18AFF6DBF49699FB6A30D44987B df75da05f7ddfe5dab740cf8339d27a65d33aac12dcfcadf11d42d920032a89e 24949d1e-fbb9-11ee-ae20-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25548 Onkološki inštitut Ljubljana 0 0 0