20.500.12556/DiRROS-18593 The role of extracellular vesicles in phenotypic cancer transformation [Pomen zunajceličnih veziklov v rakasti transformaciji celic] Background. Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids. Conclusions. Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications. rak (medicina) tumorske celice mikrovezikli biologija celice true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-04-03 14:42:23 2024-04-03 14:42:24 2024-04-04 03:35:25 0000-00-00 00:00:00 2013 0 0 Naslov v kazalu in el. verziji se razlikuje od naslova članka na str. 197; Izvleček in vzporedni stvarni naslov v slov. na str. I-VII; Besedilo članka v angl.; str. 197-205 no. 3 Vol. 47 sep. 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2013-09-01 576:616-006 1318-2099 10.2478/raon-2013-0037 269123584 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794874/ 1 42f09f32-f1af-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25368 RAZ_Ogorevc_Eva_2013.pdf RAZ_Ogorevc_Eva_2013.pdf 1 BFB6198050508AD1681F277D84B988D8 98f6478210c1439d7a1d55303c80c4a6e32fb0a9e92617e86123052866c331a2 6a975dcc-f1af-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25369 Onkološki inštitut Ljubljana 0 0 0