20.500.12556/DiRROS-18548 MRI evaluation of tibial tunnel wall cortical bone formation after platelet-rich plasma applied during anterior cruciate ligament reconstruction Background. After anterior cruciate ligament (ACL) reconstruction, formation of cortical sclerotic bone encircling the femoral and tibial tunnel is a part of intratunnel graft healing. During the physiological cascades of soft tissue healing and bone growth, cellular and hormonal factors play an important role. The purpose of this study was to noninvasively but quantitatively assess the effect of intraoperatively applied platelet-rich plasma (PRP) on the formation of cortical bone encircling the tibial tunnel. Patients and methods. In fifty patients, standard arthroscopic ACL reconstructions were performed. The PRP group (n = 25) received a local application of PRP while the control group (n = 25) did not receive PRP. The proximal tibial tunnel was examined by MRI in the paraxial plane where the portion of the tibial tunnel wall circumference consisting of sclerotic cortical bone was assessed with testing occurring at one, two and a half and six months after surgery. Results. At one month after surgery, differences between the groups in the amount of cortical sclerotic bone encircling the tunnel were not significant (p = 0.928). At two and a half months, the sclerotic portion of the tunnel wall in the PRP group (36.2%) was significantly larger than in the control (22.5%) group (p = 0.004). At six months, the portion of sclerotic bone in the PRP group (67.1%) was also significantly larger than in the control (53.5%) group (p = 0.003). Conclusions. Enhanced cortical bone formation encircling the tibial tunnel at 2.5 and 6 months after ACL graft reconstruction results from locally applied platelet-rich plasma. true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-03-22 12:08:19 2024-03-22 12:08:19 2024-03-23 03:37:32 0000-00-00 00:00:00 2013 0 0 str. 119-124, II no. 2 Vol. 47 jun. 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2013-06-01 616.728.3:617.583 1318-2099 10.2478/raon-2013-0009 22571831 http://www.degruyter.com/view/j/raon.ahead-of-print/raon-2013-0009/raon-2013-0009.xml 1 7e4f9f42-e83c-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25271 RAZ_Rupreht_Mitja_2013.pdf RAZ_Rupreht_Mitja_2013.pdf 1 A5C0D393604FF8C474A79BD4F951A2C7 df31a8d415afa34f5b88fb074b4e3a30d6c47293f1692a2f51f1e8c34c49f931 a785a1e7-e83c-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25272 Onkološki inštitut Ljubljana 0 0 0