20.500.12556/DiRROS-18521 Beta–gamma phase-amplitude coupling as a non-invasive biomarker for Parkinson’s diseas insights from Electroencephalography studies Phase-amplitude coupling (PAC) describes the interaction of two separate frequencies in which the lower frequency phase acts as a carrier frequency of the higher frequency amplitude. It is a means of carrying integrated streams of information between micro- and macroscale systems in the brain, allowing for coordinated activity of separate brain regions. A beta–gamma PAC increase over the sensorimotor cortex has been observed consistently in people with Parkinson’s disease (PD). Its cause is attributed to neural entrainment in the basal ganglia, caused by pathological degeneration characteristic of PD. Disruptions in this phenomenon in PD patients have been observed in the resting state as well as during movement recordings and have reliably distinguished patients from healthy participants. The changes can be detected non-invasively with the electroencephalogram (EEG). They correspond to the severity of the motor symptoms and the medication status of people with PD. Furthermore, a medication-induced decrease in PAC in PD correlates with the alleviation of motor symptoms measured by assessment scales. A beta–gamma PAC increase has, therefore, been explored as a possible means of quantifying motor pathology in PD. The application of this parameter to closed-loop deep brain stimulation could serve as a self-adaptation measure of such treatment, responding to fluctuations of motor symptom severity in PD. Furthermore, phase-dependent stimulation provides a new precise method for modulating PAC increases in the cortex. This review offers a comprehensive synthesis of the current EEG-based evidence on PAC fluctuations in PD, explores the potential practical utility of this biomarker, and provides recommendations for future research. neurodegenerative diseases Parkinson’s disease electroencephalography phase-amplitude coupling true false true Angleški jezik Ni določen © 2024 by the authors Neznano 2024-03-21 14:15:55 2024-03-21 14:15:56 2024-12-10 15:12:24 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 3. 2024; Soavtorji: Stiven Roytman, Nico I. Bohnen, Uros Marusic; 13 str. iss 3, [article no.] 391 Vol. 14 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2024-03-12 2024-03-15 612.67 2075-1729 10.3390/life14030391 189852419 ZRSKP_Marusic_189852419.pdf ZRSKP_Marusic_189852419.pdf 1 6374C92F5CF9F939C56FC0E590AF11D0 1ca186aad2501672557d1d590249a4cc15cbfcdacefe1b4ffb600c251d50d853 c6eeb718-e785-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25244 https://www.mdpi.com/2075-1729/14/3/391 0 281d0f79-e785-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25242 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0