20.500.12556/DiRROS-18471 Triple negative breast cancer prognostic factors and survival Background. Triple negative breast cancer (TNBC) is defined by a lack of expression of both estrogen (ER) and progesteron(PgR) receptors as well as human epidermal growth factor receptor 2 (HER2). Our retrospective analysis addressed prognostic factors for short- and long-term outcomes of patients (pts) with TNBC pts treated in routine clinical practice. Patient and methods.Our retrospective study included 269 TNBC treated at Institute of Oncology Ljubljana between March 2000 and December 2006. The collected data included patientsć, tumoursć and treatmentsć characteristics. The survival analyses were performed using the Kaplan-Meier method. The Cox proportional hazard model was used in the multivariate analysis. Results. The median age ofour patients was 55.3 yrs (23-88.5) and the median follow-up was 5.9 yrs (0.3-9.6). Six (2%) pts experienced local only, 79 (92%) pts distal recurrenceand 66 (24%) died. The predominant localisation of the first relapsewas in visceral organs (70.4%). The 5-year disease-free survival (DFS) for the entire group was 68.2% and the 5-year overall survival (OS) was 74.5%.We found a pattern of high recurrence rate in the first 3 years following the diagnosis and a clear decline in recurrence rate over the next 3years. In the univariate analysis age, nodal status, size and lymphovascular invasion (LVI) were found to have a significant impact on DFS as well as on OS. In the multivariate analysis only age (HR=1.79; 95%CI=1.14-2.82; p=0.012) and nodal status (HR=2.71; 95%CI=1.64-4.46; p<0.001) retained their independent prognostic value for DFS and for OS only the nodal status (HR=2.96; 95%CI=1.51-5.82; p=0.002). (Abstract truncated at 2000 characters) true false true Association of Radiology and Oncology Ljubljana Angleški jezik Ni določen by Authors Neznano 2024-03-19 13:02:26 2024-03-19 13:02:26 2024-03-20 03:39:23 0000-00-00 00:00:00 2011 0 0 BSDOCID156656; str. 46-52 no. 1 Vol. 45 2011 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2011-01-01 618.19-006.6 1318-2099 10.2478/v10019-010-0054.4 28183001 RAZ_Ovcaricek_Tanja_2011.pdf RAZ_Ovcaricek_Tanja_2011.pdf 1 8CC7DAE81E0E53949985C2D9D0733182 bdd78e061e18d4e4b85b19f8fb833cbf68e53bff8273549114a1b47b9519fb4e bccbb358-e5e8-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25163 Onkološki inštitut Ljubljana 0 0 0