20.500.12556/DiRROS-18469 Image cytometric nuclear texture features in inoperable head and neck cancer a pilot study Background. Image cytometry can measure numerous nuclear features which could be considered a surrogate end-point marker of molecular genetic changes in a nucleus. The aim of the study was to analyze image cytometric nuclear featuresin paired samples of primary tumor and neck metastasis in patients with inoperable carcinoma of the head and neck. Materials and methods. Image cytometric analysis of cell suspensions prepared from primary tumor tissue andfine needle aspiration biopsy cell samples of neck metastases from 21 patients treated with concomitant radiochemotherapy was performed. Nuclear features were correlated with clinical characteristics and response to therapy. Results. Manifestation of distant metastases and new primaries was associated (p<0.05) with several chromatin characteristics from primary tumor cells, whereas the origin of index cancer and disease response in the neck wasrelated to those in the cells from metastases. Many nuclear features of primary tumors and metastases correlated with the TNM stage. Conclusions. A specific pattern of correlation between well-established prognostic indicatorsand nuclear features of samples from primary tumors and those from neck metastases was observed. Image cytometric nuclear features represent a promising candidate marker for recognition of biologically different tumor subgroups. true false true Association of Radiology and Oncology Ljubljana Angleški jezik Ni določen by Authors Neznano 2024-03-19 12:51:12 2024-03-19 12:51:12 2024-03-20 03:39:23 0000-00-00 00:00:00 2011 0 0 BSDOCID156653; str. 40-45 no. 1 Vol. 45 2011 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2011-01-01 616-006.6:611.91/.93 1318-2099 10.2478/v10019-011-0002-y 28182745 RAZ_Strojan_Flezar_Margareta_2011.pdf RAZ_Strojan_Flezar_Margareta_2011.pdf 1 6900554E107E8CC4AD3EE352FDC860AC 085e25d997b420f659d39151d6ae74c0d8c673bbe6c8e9c51c8a016b512098db 2fae0839-e5e7-11ee-9dd4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=25162 Onkološki inštitut Ljubljana 0 0 0