20.500.12556/DiRROS-18183 Schedule-dependency of doxorubicin and vinblastine in EAT tumours in mice [Pomen različnih shem zdravljenja z deksorubicinom in vinblastinom na EAT tumorjih pri miših] Background. Antitumour schedule-dependency of the doxorubicin and vinblastine combination was explored. Materials and methods. Intraperitoneal Ehrlich ascites tumours (EAT) syngeneic to CBA mice were treated with vinblastine ar doxorubicin alone, or in combined treatment schedules. Results. Combinations of doxorubicin and vinblasfine administered at 48-h, but not at 24-h interval,regardless of the sequence of drugs, significantly reduced the numberof tumour cells in the ascites in corrtparison with all other treatments. In the combined treatment schedules, the predominant morphologicalchanges as well as DNA distribution pattern were dependent on thefirst drug applied. Regardless of the sequence of the drugs, median survival times of animals did not significantly differ between the treatment groups. Conclusions. The effect of combination of vinblastine and doxorubicin is schedule-dependent. The time interval, but not the sequence of drugs seems to be crucial for the observed effect. The data from preclinical studies are important for planning combined treatment schedules in clinical setting. true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-02-15 14:01:22 2024-02-15 14:01:23 2024-02-16 03:38:36 0000-00-00 00:00:00 2006 0 0 str. 245-257 no. 4 Vol. 40 2006 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2006-01-01 616-006 1318-2099 423547 RAZ_Auersperg_Marija_2006.pdf RAZ_Auersperg_Marija_2006.pdf 1 0885E4435D8C742E613C7AE9E834157F 227dc9c5a5397a05bf2f47961481f619eb8c6b23d7d43fad67eab9590cf4b956 1c9811d2-cbfa-11ee-aa6e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=24694 Onkološki inštitut Ljubljana 0 0 0