20.500.12556/DiRROS-18166 The dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis Z dimetilhidrazinom inducirani tumorji debelega črevesa in danke pri podgani Animal models of colorectal carcinogenesis represent invaluable research tool for investigating colorectal cancer (CRC). Experimentally induced tumours in laboratory animals provide opportunity for studying certain aspects of tumoursthat cannot be effectively studied in humans. Significant information on human CRC aetiology or factors influencing it has derived from studies using dimethylhydrazine (DMH) model that is one of the experimental models appreciated for its morphological similarity to human CRC. Today, DMH model represents useful research tool for the studies of colon carcinogens and chemopreventive agents. The review offers insight into morphogenesis and genetic alterations of DMH induced colorectal epithelial tumours in rats. Živalski modeli so pri raziskavah raka na debelem črevesju in danki nepogrešljivi, saj omogočajo raziskovanje in testiranje številnih dejavnikov, ki jih ni mogoče neposredno ugotavljati pri ljudeh. Edinega izmed živalskih modelov raka na debelem črevesju in danki predstavljajo z dimetilhidrazinom (DMH) inducirane podgane, ki razvijejo tumorje debelega črevesa in danke zelo podobne humanim. S člankom želimo predstaviti morfološke in genetske spremembetega modela, ki je veliko prispeval k današnjemu poznavanju etioloških in drugih dejavnikov, ki vplivajo na nastanek in razvoj raka. Danespa je nepogrešljiv pri raziskavah črevesnih karcinogenov in kemopreventivnih substanc. true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2024-02-14 12:49:13 2024-02-14 12:49:13 2024-02-15 03:42:34 0000-00-00 00:00:00 2005 0 0 BSDOCID113173; str. 61-70 št. 1 Letn. 39 2005 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2005-01-01 616 1318-2099 19252953 RAZ_Perse_Martina_2005.pdf RAZ_Perse_Martina_2005.pdf 1 88A5654EAB5D15EDB6C5F98E0BD7D64E 65197fb3404b48bf9281a2f26641848c676a13c75691942babb5b16b1bcb3dd6 e60845a0-cb26-11ee-aa6e-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=24676 Onkološki inštitut Ljubljana 0 0 0