20.500.12556/DiRROS-17990 Combined therapy for oral cavity and oropharyngeal squamous cell carcinoma depth of invasion as prognostic factor Background. The aim of the study was to emphasize the importance of surgical management of squamous cell carcinoma (SCC) in the head and neck to find the most important predictive factor for cervical lymph node metastasis and prognostic factor for survival. The use of multimodality therapy is being discussed as well. Patients and methods. From June 1st, 1992 to May 31st, 1998, 154 patients with oral cavity and oropharyngeal SCC were admitted to the Department of Otorhinolaryngology and Cervicofacial Surgery in the Teaching Hospital of Maribor. The criteria for inclusion into the study were met by 142 patients, but only 62/142 patients entered the multimodality protocol (surgery and postoperative radiotherapy). These 62/142 patients were treated surgically and 49 of them were postoperatively irradiated, while 13/62 declined postoperative radiotherapy. Surgical specimen was evaluated for positive or negative lymph nodes, tumor margins and the depth of invasion. Tumor cells were stained for Ki67 proliferative factor. Results. The depth of invasion was the most important predictive factor for the neck metastases in multivariate model including also the grade, pT and T. pN was found to be important in determining the overall survival using Cox regression model (p>0,05). A statistically important discrepancy between N and pN classification was found. In 23 cases N was overrated and in 3 cases underrated. The overall 5-year disease specific survival was 55%. Ki67 correlated with the grade of tumor differentiation. No statistically significant correlation was found with lymph node metastases. Conclusions. The depth of invasion is the most important determining the occurrence of the neck metastases whereas the N status determines the survival. true false true Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society Ljubljana Angleški jezik Ni določen by Authors Neznano 2024-01-25 13:17:16 2024-01-25 13:17:17 2024-01-26 03:50:48 0000-00-00 00:00:00 2001 0 0 Soavtorji: Boštjan Lanišnik, Vojko Didanovič, Kristina Kramberger; str. 255-258 no. 4 Vol. 35 Dec. 2001 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2001-12-01 616.21 1318-2099 863551 RAZ_Cizmarevic_Bogdan_2001.pdf RAZ_Cizmarevic_Bogdan_2001.pdf 1 EA10CFD8202A28E030C913A3F5EC7D85 44ce12fbee35f72712dc7556fa5aef7ec2825014578fade10a3f763c6cd33a65 f1ccd845-bb7c-11ee-b0d4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=24409 Onkološki inštitut Ljubljana 0 0 0