20.500.12556/DiRROS-17527 Between but not within-species variation in the distribution of fitness effects New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is, therefore, of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, that is whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterized the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence, and genetic background. We find statistical support for the presence of variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and those evolutionarily recent events, such as demographic changes and local adaptation, have little impact. DFE deleterious mutations population structure forest trees škodljive mutacije populacijska struktura gozdno drevje true false true Angleški jezik Slovenski jezik Neznano 2023-12-12 13:50:16 2023-12-12 13:50:17 2023-12-13 03:39:15 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 12. 2023; Število sodelavcev v konzorciju GenTree Consortium: 128; Sodelavca pri raziskavi: M. Bajc. M. Westergen; str. 1-16 iss. 11 Vol. 40 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 630*16 1537-1719 10.1093/molbev/msad228 177091075 https://academic.oup.com/mbe/article/40/11/msad228/7313554 1 a2d54cb0-98e4-11ee-9ccb-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=23821 RAZ_James_Jennifer_2023.pdf RAZ_James_Jennifer_2023.pdf 1 9E1BED654595E08285DCADD798AE54EB 7c127f2f7c73867bd29faa775da99b9fcdd1e51738266678c1c3e28153ebd258 b990c57f-98e4-11ee-9ccb-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=23822 Gozdarski inštitut Slovenije 0 0 0